Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, 241-0815, Japan.
Gastric Cancer. 2010 Jun;13(2):63-73. doi: 10.1007/s10120-010-0555-2. Epub 2010 Jul 3.
The incidence of adenocarcinoma of the esophagogastric junction (AEG) is dramatically increasing in Western countries, while it is not increasing in Eastern countries. Siewert type I tumors are observed less frequently in Eastern countries in comparison to Western countries. On the other hand, other clinicopathological features of AEG, including age, male-to-female ratio, pathological grade, tumor progression, and prognosis, are similar in Western and Eastern countries. Two surgical phase III trials have indicated that AEG type I should be treated surgically as esophageal cancer, while types II and III should be regarded as true gastric cancer. No phase III trials have demonstrated a significant interaction comparing hazard ratios for death between AEG and true gastric cancer in the subset analyses with regard to chemotherapy.
食管胃结合部腺癌（AEG）在西方国家的发病率显著增加，而在东方国家则没有增加。与西方国家相比，东方国家观察到的 Siewert Ⅰ型肿瘤较少。另一方面，AEG 的其他临床病理特征，包括年龄、男女比例、病理分级、肿瘤进展和预后，在西方国家和东方国家是相似的。两项外科 III 期临床试验表明，AEG Ⅰ型应作为食管癌进行手术治疗，而Ⅱ型和Ⅲ型应视为真正的胃癌。在亚组分析中，没有 III 期临床试验表明在化疗方面，AEG 和真正的胃癌之间的死亡风险比存在显著的相互作用。
