Liu Fang, Wei Lai, Zheng Bosheng, Su Xin, Ju Jianmei, Liu Guangjie, Liu Qingyi
Department of Hospital Quality and Control, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050001, P.R. China.
Department of Thoracic Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050001, P.R. China.
Oncol Lett. 2024 May 14;28(1):321. doi: 10.3892/ol.2024.14454. eCollection 2024 Jul.
Esophagogastric junction adenocarcinoma (EJA) has increased in recent years, and it exhibits a poor prognosis and a short survival period for patients. Hydrogen sulfide (HS) plays an important role in the pathogenesis of cancer and has been studied as a diagnostic factor in some tumor diseases. However, few studies have explored the diagnostic value of HS for EJA. In the present study, a total of 56 patients with early-stage EJA were enrolled while 57 healthy individuals were selected as the healthy control group. Clinical features were recorded, and exhaled HS and blood samples were collected from both groups. Exhaled HS and serum interleukin-8 (IL-8) expression levels were detected in both groups. The correlation between exhaled HS and serum IL-8 levels was analyzed using Pearson's correlation method. Receiver operating characteristic (ROC) curve was used to evaluate the diagnostic value of exhaled HS combined with IL-8 detection in EJA. The results showed that patients with EJA exhaled more HS than healthy individuals. In addition, exhaled HS was positively correlated with increased IL-8 expression. The ROC curve revealed that the exhaled HS test had an acceptable diagnostic effect and could be used to diagnose EJA. The increase in HS exhaled by patients with EJA indicated that HS may be related to the occurrence and development of EJA; however, the mechanism needs to be further explored. Collectively, it was determined in the present study that exhaled HS was significantly higher in patients with early-stage EJA than in healthy controls and combined diagnosis with patient serum IL-8 could improve diagnostic accuracy, which has potential diagnostic value for early diagnosis and screening of EJA.
近年来，食管胃交界腺癌（EJA）的发病率有所上升，患者预后较差，生存期较短。硫化氢（HS）在癌症发病机制中起重要作用，并且已作为某些肿瘤疾病的诊断因素进行研究。然而，很少有研究探讨HS对EJA的诊断价值。在本研究中，共纳入56例早期EJA患者，同时选取57名健康个体作为健康对照组。记录临床特征，并收集两组的呼出HS和血液样本。检测两组呼出HS和血清白细胞介素-8（IL-8）表达水平。采用Pearson相关法分析呼出HS与血清IL-8水平的相关性。采用受试者工作特征（ROC）曲线评估呼出HS联合IL-8检测在EJA中的诊断价值。结果显示，EJA患者呼出的HS比健康个体更多。此外，呼出HS与IL-8表达增加呈正相关。ROC曲线显示，呼出HS检测具有可接受的诊断效果，可用于诊断EJA。EJA患者呼出HS增加表明HS可能与EJA的发生发展有关；然而，其机制有待进一步探索。总体而言，本研究确定早期EJA患者呼出的HS明显高于健康对照组，联合检测患者血清IL-8可提高诊断准确性，这对EJA的早期诊断和筛查具有潜在的诊断价值。
