Shibata S
Department of Neurosurgery, Nagasaki University School of Medicine.
Rinsho Shinkeigaku. 1991 Feb;31(2):159-62.
Primary intracerebral malignant lymphoma is non-Hodgkin's lymphoma originating in the central nervous system. It is a rare disease, comprising 1% of all brain tumors and 1.6% of extranodal non-Hodgkin's lymphoma, but its frequency has increased recently in aged patients. The ages of the 10 patients (8 men and 2 women) ranged from 31 to 79 years and average 56 years. In 5 patients over 60 years old (mean age 72), a solitary lesion was found in 2 patients and multiple lesions in 3 patients on a contrast-enhanced scan. One patients are still alive, but 4 died, after surviving 4 months on average. In 5 patients under 60 years old (average 39), single lesion were present in 4 and multiple in 1. Two patients are still alive three patients have died. Their median survival was 4 years and 11 months. In conclusion, primary intracerebral malignant lymphoma increased frequency in aged patients. Their tumors were generally larger and more often multiple, and their prognosis was definitely poor.
原发性脑内恶性淋巴瘤是起源于中枢神经系统的非霍奇金淋巴瘤。它是一种罕见疾病，占所有脑肿瘤的1%，占结外非霍奇金淋巴瘤的1.6%，但其发病率最近在老年患者中有所增加。10例患者（8例男性和2例女性）年龄在31至79岁之间，平均56岁。在5例60岁以上患者（平均年龄72岁）中，增强扫描发现2例为孤立性病变，3例为多发病变。1例患者仍存活，但4例死亡，平均存活4个月后死亡。在5例60岁以下患者（平均39岁）中，4例为单发病变，1例为多发病变。2例患者仍存活，3例患者已死亡。他们的中位生存期为4年11个月。总之，原发性脑内恶性淋巴瘤在老年患者中的发病率增加。他们的肿瘤通常更大，且更常为多发病变，其预后肯定较差。
