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类风湿关节炎中糖皮质激素的应用——尚无“合理”方法。

The use of glucocorticoids in rheumatoid arthritis--no 'rational' approach yet.

机构信息

Brigham and Women's Hospital, Division of Rheumatology, Immunology, and Allergy, 75 Francis Street, Boston, MA 02115, USA.

出版信息

Arthritis Res Ther. 2010;12(3):127. doi: 10.1186/ar3035. Epub 2010 Jun 25.

DOI:10.1186/ar3035
PMID:20602811
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2911892/
Abstract

The relationship between glucocorticoids and bone mineral density in rheumatoid arthritis is complex. Further study into the optimal dosing, timing and duration of glucocorticoid use in rheumatoid arthritis is necessary.

摘要

类风湿关节炎中糖皮质激素与骨密度的关系较为复杂。有必要进一步研究类风湿关节炎中糖皮质激素的最佳剂量、时机和使用持续时间。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/077c/2911892/242ea0c14052/ar3035-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/077c/2911892/70b24f628191/ar3035-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/077c/2911892/242ea0c14052/ar3035-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/077c/2911892/70b24f628191/ar3035-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/077c/2911892/242ea0c14052/ar3035-2.jpg

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本文引用的文献

1
A rational use of glucocorticoids in patients with early arthritis has a minimal impact on bone mass.早期关节炎患者合理使用糖皮质激素对骨量的影响极小。
Arthritis Res Ther. 2010;12(2):R50. doi: 10.1186/ar2961. Epub 2010 Mar 23.
2
Clinical features associated with glucocorticoid receptor polymorphisms. An overview.与糖皮质激素受体基因多态性相关的临床特征。综述。
Ann N Y Acad Sci. 2009 Oct;1179:179-98. doi: 10.1111/j.1749-6632.2009.05013.x.
3
Osteoimmunology in rheumatic diseases.风湿性疾病中的骨免疫学
Arthritis Res Ther. 2009;11(1):210. doi: 10.1186/ar2571. Epub 2009 Jan 30.
4
Impact of low-dose prednisolone on bone synthesis and resorption in early rheumatoid arthritis: experiences from a two-year randomized study.低剂量泼尼松龙对早期类风湿关节炎骨合成与骨吸收的影响:一项为期两年的随机研究经验
Arthritis Res Ther. 2008;10(6):R128. doi: 10.1186/ar2542. Epub 2008 Nov 5.
5
The effect of methylprednisolone on proliferation of PBMCs obtained from steroid-sensitive and steroid-resistant rheumatoid arthritis patients.甲泼尼龙对从激素敏感型和激素抵抗型类风湿关节炎患者获取的外周血单核细胞增殖的影响。
Scand J Rheumatol. 2007 May-Jun;36(3):167-71. doi: 10.1080/03009740601154111.
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Glucocorticoid-induced osteoporosis: pathophysiology and therapy.糖皮质激素性骨质疏松症:病理生理学与治疗
Osteoporos Int. 2007 Oct;18(10):1319-28. doi: 10.1007/s00198-007-0394-0. Epub 2007 Jun 14.
7
Effects of glucocorticoids on radiological progression in rheumatoid arthritis.糖皮质激素对类风湿关节炎影像学进展的影响。
Cochrane Database Syst Rev. 2007 Jan 24;2007(1):CD006356. doi: 10.1002/14651858.CD006356.
8
Reduced loss of hand bone density with prednisolone in early rheumatoid arthritis: results from a randomized placebo-controlled trial.泼尼松龙可减少早期类风湿关节炎患者手部骨密度的流失:一项随机安慰剂对照试验的结果
Arch Intern Med. 2005 Jun 13;165(11):1293-7. doi: 10.1001/archinte.165.11.1293.
9
Effects of low-dose prednisone on bone metabolism.小剂量泼尼松对骨代谢的影响。
J Bone Miner Res. 2005 Mar;20(3):464-70. doi: 10.1359/JBMR.041125. Epub 2004 Nov 29.
10
Identification of cell types responsible for bone resorption in rheumatoid arthritis and juvenile rheumatoid arthritis.类风湿关节炎和幼年类风湿关节炎中负责骨吸收的细胞类型鉴定。
Am J Pathol. 1998 Apr;152(4):943-51.