Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, UK.
Cell. 2010 Jun 25;141(7):1114-6. doi: 10.1016/j.cell.2010.06.015.
Information obtained from genome-wide association studies has cracked open the biology of common chronic diseases by identifying genes that predispose individuals to these disorders. Cadwell et al. (2010) now demonstrate that a viral infection, a toxic insult to the gut, commensal bacteria, and a Crohn's disease susceptibility gene collude to cause inflammatory disease in the mouse gut.
全基因组关联研究获得的信息通过鉴定使个体易患这些疾病的基因，揭示了常见慢性疾病的生物学机制。Cadwell 等人（2010 年）现在证明，病毒感染、肠道的毒性损伤、共生细菌和克罗恩病易感性基因共同导致了小鼠肠道的炎症性疾病。
