十年遗传学和基因组学：我们取得了哪些成就，未来的方向在哪里？
Ten years of genetics and genomics: what have we achieved and where are we heading?
机构信息
INSERM U/CNRS UMR, Institut Curie - Centre de Recherche, Paris, France.
出版信息
Nat Rev Genet. 2010 Oct;11(10):723-33. doi: 10.1038/nrg2878. Epub 2010 Sep 7.
Abstract
To celebrate the first 10 years of Nature Reviews Genetics, we asked eight leading researchers for their views on the key developments in genetics and genomics in the past decade and the prospects for the future. Their responses highlight the incredible changes that the field has seen, from the explosion of genomic data and the many possibilities it has opened up to the ability to reprogramme adult cells to pluripotency. The way ahead looks similarly exciting as we address questions such as how cells function as systems and how complex interactions among genetics, epigenetics and the environment combine to shape phenotypes.
摘要
为庆祝《自然评论遗传学》创刊 10 周年，我们邀请了 8 位顶尖研究人员，就过去 10 年中遗传学和基因组学的主要发展以及未来前景发表看法。他们的回应突出了该领域所经历的令人难以置信的变化，从基因组数据的爆炸式增长及其带来的诸多可能性，到能够将成体细胞重新编程为多能性。当我们解决细胞如何作为系统发挥功能以及遗传、表观遗传和环境之间的复杂相互作用如何结合来塑造表型等问题时，未来的前景同样令人兴奋。
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