The London Centre for Nanotechnology, University College London, Gower Street, London WC1E 6BT, UK.
Philos Trans A Math Phys Eng Sci. 2010 Aug 13;368(1924):3491-502. doi: 10.1098/rsta.2010.0117.
Human sensory processes are well understood: hearing, seeing, perhaps even tasting and touch--but we do not understand smell--the elusive sense. That is, for the others we know what stimuli causes what response, and why and how. These fundamental questions are not answered within the sphere of smell science; we do not know what it is about a molecule that ... smells. I report, here, the status quo theories for olfaction, highlighting what we do not know, and explaining why dismissing the perception of the input as 'too subjective' acts as a roadblock not conducive to scientific inquiry. I outline the current and new theory that conjectures a mechanism for signal transduction based on quantum mechanical phenomena, dubbed the 'swipe card', which is perhaps controversial but feasible. I show that such lines of thinking may answer some questions, or at least pose the right questions. Most importantly, I draw links and comparisons as to how better understanding of how small (10's of atoms) molecules can interact so specially with large (10,000's of atoms) proteins in a way that is so integral to healthy living. Repercussions of this work are not just important in understanding a basic scientific tool used by us all, but often taken for granted, it is also a step closer to understanding generic mechanisms between drug and receptor, for example.
听觉、视觉,甚至可能包括味觉和触觉——但我们不了解嗅觉——这种难以捉摸的感觉。也就是说,对于其他感觉,我们知道什么刺激会引起什么反应,以及为什么和如何引起。这些基本问题在嗅觉科学领域没有得到解答;我们不知道是什么使一个分子具有……气味。我在这里报告嗅觉的现状理论,强调我们不知道的地方,并解释为什么将输入的感知视为“过于主观”会成为不利于科学探究的障碍。我概述了当前和新的理论,该理论推测了一种基于量子力学现象的信号转导机制,称为“刷卡”,这也许有争议,但却是可行的。我表明,这种思路可能会回答一些问题,或者至少提出正确的问题。最重要的是,我将联系和比较如何更好地理解小分子(数十个原子)如何与大蛋白(数千个原子)如此特殊地相互作用,因为这对健康生活至关重要。这项工作的影响不仅在于理解我们所有人都使用的基本科学工具,而且往往被视为理所当然,它也更接近于理解药物和受体之间的一般机制,例如。