Department of Orthopaedic Surgery, Osaka City University Graduate School of Medicine, Japan.
J Tissue Eng Regen Med. 2011 Feb;5(2):146-50. doi: 10.1002/term.299.
Among autologous somatic stem cells, bone marrow-derived mesenchymal stem cells (BMSCs) are the most widely used worldwide to repair not only mesenchymal tissues (bone, cartilage) but also many other kinds of tissues, including heart, skin, and liver. Autologous BMSCs are thought to be safe because of the absence of immunological reaction and disease transmission. However, it is possible that they will form tumours during long-term follow-up. In 1988, we transplanted autologous BMSCs to repair articular cartilage, which was the first such trial ever reported. Subsequently we performed this procedure in about 40 patients. Demonstration that neither partial infections nor tumours appeared in these patients provided strong evidence for the safety of autologous BMSC transplantation. Thus, in this study we checked these patients for tumour development and infections. Between January 1998 and November 2008, 41 patients received 45 transplantations. We checked their records until their last visit. We telephoned or mailed the patients who had not visited the clinics recently to establish whether there were any abnormalities in the operated joints. Neither tumours nor infections were observed between 5 and 137 (mean 75) months of follow-up. Autologous BMSC transplantation is a safe procedure and will be widely used around the world.
在自体成体干细胞中，骨髓间充质干细胞（BMSCs）是全球应用最广泛的，不仅可用于修复间充质组织（骨、软骨），还可用于修复多种其他组织，包括心脏、皮肤和肝脏。由于不存在免疫反应和疾病传播，自体 BMSCs 被认为是安全的。然而，在长期随访中，它们有可能形成肿瘤。1988 年，我们首次报道了用自体 BMSCs 移植修复关节软骨。随后，我们对大约 40 名患者进行了这项操作。这些患者既没有出现局部感染，也没有出现肿瘤，这为自体 BMSC 移植的安全性提供了有力证据。因此，在这项研究中，我们检查了这些患者是否有肿瘤发展和感染的情况。1998 年 1 月至 2008 年 11 月，有 41 名患者接受了 45 次移植。我们对他们的记录进行了检查，直到他们最后一次就诊。我们打电话或寄信给最近没有到诊所就诊的患者，以确定手术关节是否有任何异常。在 5 至 137 个月（平均 75 个月）的随访中，既没有观察到肿瘤，也没有观察到感染。自体 BMSC 移植是一种安全的操作，将在全球范围内得到广泛应用。
