Bull World Health Organ. 1963;29 Suppl(Suppl):69-76.
In order to provide a rational basis for the development of new insecticides, a thorough understanding of resistance mechanisms is necessary and this presupposes a detailed knowledge of the normal biochemical pathways in insects. The author reviews recent progress in this field, particularly the work on enzymatic detoxication of insecticides which appears to be the most important single factor in the production of resistance. The mechanisms include dehydrochlorination and alpha-methylenic oxidation (DDT), hydrolysis by phosphatases or carboxyesterases (organophosphorus compounds), and oxidation by microsomal enzyme systems (various classes of insecticides). Much work still needs to be done on the enzyme systems involved, especially in relation to substrate specificity and the effect of enzyme inhibitors that might act as synergists of insecticides.
为了为新杀虫剂的开发提供合理的依据，深入了解抗性机制是必要的，这就需要详细了解昆虫的正常生化途径。作者回顾了这一领域的最新进展，特别是关于杀虫剂酶解毒的工作，这似乎是产生抗性的最重要的单一因素。这些机制包括脱氯化氢和α-亚甲基氧化（DDT）、磷酸酶或羧酸酯酶水解（有机磷化合物）以及微粒体酶系统氧化（各种类别的杀虫剂）。仍需要对涉及的酶系统进行大量的研究，特别是在与底物特异性和可能作为杀虫剂增效剂的酶抑制剂的作用有关的方面。
