Oppenoorth F J
Bull World Health Organ. 1971;44(1-3):195-202.
(1) the importance of detoxification as a resistance mechanism and the extent to which synergists could contribute to a solution of the resistance problem, and (2) the role of detoxification as a cause of selectivity, and whether the loss in selectivity that might result from the use of synergists would be a disadvantage. If insecticides could be combined with detoxification-blocking synergists, a much wider range of insecticides might become available for use.This paper also discusses the relative importance of different routes of detoxification, whether to use a constant synergist-insecticide ratio, and some recent work carried out in the author's laboratory on microsomal oxidation of paraoxon and on the synergistic action of P=S compounds.
（1）解毒作用作为一种抗性机制的重要性以及增效剂在解决抗性问题方面可发挥作用的程度，（2）解毒作用作为选择性产生原因的作用，以及使用增效剂可能导致的选择性丧失是否会成为一个不利因素。如果杀虫剂能够与解毒阻断增效剂相结合，那么可供使用的杀虫剂种类可能会大大增加。本文还讨论了不同解毒途径的相对重要性、是否使用恒定的增效剂与杀虫剂比例，以及作者实验室最近关于对氧磷微粒体氧化和P=S化合物增效作用的一些研究工作。
