稳定的 α-螺旋催化的 α,β-不饱和酮的对映选择性环氧化。

Stabilized alpha-helix-catalyzed enantioselective epoxidation of alpha,beta-unsaturated ketones.

机构信息

Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.

出版信息

Org Lett. 2010 Aug 6;12(15):3564-6. doi: 10.1021/ol101435w.

PMID:20604529

Abstract

Chiral cyclic alpha-amino acid containing oligopeptide catalyzed highly enantioselective epoxidation of alpha,beta-unsaturated ketones and the alpha-helical secondary structure of the peptide catalyst were revealed by X-ray crystallographic analysis.

摘要

手性环状α-氨基酸含寡肽催化的α，β-不饱和酮的高对映选择性环氧化反应和肽催化剂的α-螺旋二级结构通过 X 射线晶体学分析得到揭示。