Barry J A, Kay A R, Navaratnarajah R, Iqbal S, Bamfo J E A K, David A L, Hines M, Hardiman P J
Department of Psychology, City University, London, UK.
J Obstet Gynaecol. 2010;30(5):444-6. doi: 10.3109/01443615.2010.485254.
The aetiology of polycystic ovary syndrome (PCOS) is poorly understood, but an intrauterine hyperandrogenic environment has been implicated. This study was designed to assess whether the female offspring of mothers with PCOS are exposed to raised levels of testosterone (T) in utero. In this case-control study, three groups of pregnant women were recruited from the labour ward: PCOS women with a female baby (n = 10, PCOS girls); control women with a female baby (n = 20, control girls) and control women with a male baby (n = 10, control boys). Maternal and umbilical vein (UV) blood was assayed for T levels. UV T in PCOS girls was significantly raised, compared with control girls (p < 0.012). The difference in UV T between PCOS girls and control boys was not significant (p < 0.254). This is the first demonstration of a hyperandrogenic in utero environment in PCOS pregnancies; UV T in female infants is raised to male levels.
多囊卵巢综合征（PCOS）的病因尚不清楚，但子宫内雄激素过多的环境被认为与之有关。本研究旨在评估患有PCOS的母亲的女性后代在子宫内是否暴露于升高的睾酮（T）水平。在这项病例对照研究中，从产房招募了三组孕妇：有女婴的PCOS女性（n = 10，PCOS女孩）；有女婴的对照女性（n = 20，对照女孩）和有男婴的对照女性（n = 10，对照男孩）。检测母体和脐静脉（UV）血中的T水平。与对照女孩相比，PCOS女孩的UV T显著升高（p < 0.012）。PCOS女孩和对照男孩之间的UV T差异不显著（p < 0.254）。这是首次证明PCOS妊娠子宫内存在雄激素过多的环境；女婴的UV T升高至男婴水平。
