Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
The Foundation for Research & Education Excellence, Vestavia Hills, AL, USA.
J Endocrinol Invest. 2024 Nov;47(11):2731-2743. doi: 10.1007/s40618-024-02374-7. Epub 2024 Apr 22.
There is limited research on the effects of maternal hyperandrogenism (MHA) on cardiometabolic risk factors in male offspring. We aimed to compare the risk of metabolic syndrome (MetS) in sons of women with preconceptional hyperandrogenism (HA) to those of non-HA women in later life.
Using data obtained from the Tehran Lipid and Glucose Cohort Study, with an average of 20 years follow-up, 1913 sons were divided into two groups based on their MHA status, sons with MHA (n = 523) and sons without MHA (controls n = 1390). The study groups were monitored from the baseline until either the incidence of events, censoring, or the end of the study period, depending on which occurred first. Age-scaled unadjusted and adjusted Cox regression models were utilized to evaluate the hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between MHA and MetS in their sons.
There was no significant association between MHA and HR of MetS in sons with MHA compared to controls, even after adjustment (unadjusted HR (95% CI) 0.94 (0.80-1.11), P = 0.5) and (adjusted HR (95% CI) 0.98 (0.81-1.18), P = 0.8). Sons with MHA showed a HR of 1.35 for developing high fasting blood sugar compared to controls (unadjusted HR (95% CI) 1.35 (1.01-1.81), P = 0.04), however, after adjustment this association did not remain significant (adjusted HR (95% CI) 1.25 (0.90-1.74), P = 0.1).
The results suggest that preconceptional MHA doesn't increase the risk of developing MetS in sons in later life. According to this suggestion, preconceptional MHA may not have long-term metabolic consequences in male offspring.
关于母体高雄激素血症（MHA）对男性后代心血管代谢危险因素的影响，研究有限。我们旨在比较患有高雄激素血症（HA）的女性在受孕前的儿子与非 HA 女性在以后的生活中代谢综合征（MetS）的风险。
利用德黑兰血脂和血糖队列研究的数据，平均随访 20 年，1913 名儿子根据 MHA 状况分为两组，高雄激素血症的儿子（n=523）和没有 MHA 的儿子（对照组 n=1390）。研究组从基线开始监测，直到发生事件、删失或研究期结束，以先发生者为准。利用年龄标化的未调整和调整的 Cox 回归模型评估 MHA 与儿子代谢综合征之间的关联的风险比（HR）和 95%置信区间（CI）。
与对照组相比，高雄激素血症的儿子中 MHA 与 MetS 的 HR 无显著相关性，即使在调整后也是如此（未调整 HR（95%CI）0.94（0.80-1.11），P=0.5）和（调整 HR（95%CI）0.98（0.81-1.18），P=0.8）。与对照组相比，高雄激素血症的儿子发生高空腹血糖的 HR 为 1.35（未调整 HR（95%CI）1.35（1.01-1.81），P=0.04），但调整后这种相关性不再显著（调整 HR（95%CI）1.25（0.90-1.74），P=0.1）。
结果表明，受孕前 MHA 不会增加儿子以后发生 MetS 的风险。根据这一建议，受孕前 MHA 可能不会对男性后代产生长期的代谢后果。
