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1976年至1985年法国科多尔省结直肠癌的术后死亡率

[Postoperative mortality for colorectal cancer in the Côte-d'Or (France) from 1976 to 1985].

作者信息

Meny B, Milan C, Bedenne L, Pillon D, Arveux P, Hillon P, Faivre J

机构信息

Equipe associée INSERM-DGS, Faculté de Médecine, Dijon.

出版信息

Gastroenterol Clin Biol. 1991;15(4):306-10.

PMID:2060741
Abstract

Postoperative mortality from colorectal cancers in the resident population of the department of Côte-d'Or was studied for the 1976-1985 period through the data collected by the Registry of Digestive Tumors of the Côte-d'Or (France). The overall postoperative mortality was 14.7 percent for colonic cancers and 11.2 percent for rectal cancers. After surgery with curative intent (n = 1,411), the corresponding figures were 10.3 percent and 6.8 percent, respectively. In patients operated with curative intent, postoperative mortality was slightly less in females than in males (NS), and in patients less than 65 than in older patients (P less than 0.001). It was higher when cancer was discovered through an acute event (20.0 percent) than in the other patients (7.7 percent; P less than 0.001). Stage at diagnosis, gross macroscopical appearance, and tumour size had no influence on postoperative mortality for colonic cancers. For rectal cancers, postoperative mortality was lower in tumors less than 3 cm in diameter (1.3 percent) than in larger tumors (7.5 percent; P less than 0.05). Postoperative mortality decreased by a mean of 9.7 percent per year between 1976 and 1985 (P less than 0.001). This trend was more pronounced after curative surgery: 10.9 percent (P less than 0.001) than after palliative surgery: 5.5 percent (P less than 0.05). After curative surgery, postoperative mortality decreased more in men (annual variation: 13.9 percent; P less than 0.001) than in women (6.3 percent; NS), before age 75 (20.2 percent; P less than 0.001) than in older patients (5.6 percent; NS), and for colonic cancers (13.1 percent; P less than 0.001) than for rectal cancers (9.1 percent; NS).(ABSTRACT TRUNCATED AT 250 WORDS)

摘要

通过法国科多尔省消化肿瘤登记处收集的数据,对1976 - 1985年期间科多尔省居民人群中结直肠癌的术后死亡率进行了研究。结肠癌的总体术后死亡率为14.7%,直肠癌为11.2%。在进行根治性手术的患者中(n = 1411),相应数字分别为10.3%和6.8%。在接受根治性手术的患者中,女性术后死亡率略低于男性(无统计学差异),65岁以下患者低于老年患者(P < 0.001)。因急性事件发现癌症时的术后死亡率(20.0%)高于其他患者(7.7%;P < 0.001)。诊断时的分期、大体宏观表现和肿瘤大小对结肠癌的术后死亡率没有影响。对于直肠癌,直径小于3 cm的肿瘤术后死亡率(1.3%)低于较大肿瘤(7.5%;P < 0.05)。1976年至1985年间,术后死亡率平均每年下降9.7%(P < 0.001)。这种趋势在根治性手术后更为明显:下降10.9%(P < 0.001),而姑息性手术后为5.5%(P < 0.05)。根治性手术后,男性术后死亡率下降幅度(年变化:13.9%;P < 0.001)大于女性(6.3%;无统计学差异),75岁之前(20.2%;P < 0.001)大于老年患者(5.6%;无统计学差异),结肠癌(13.1%;P < 0.001)大于直肠癌(9.1%;无统计学差异)。(摘要截断于250字)

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