Institute for Biomedical Research, Kaunas University of Medicine, Kaunas, Lithuania.
Breast Cancer Res Treat. 2011 Jan;125(2):511-7. doi: 10.1007/s10549-010-1007-8. Epub 2010 Jul 6.
The study aimed to determine and compare cadmium (Cd) concentration in different biological media of breast cancer and benign breast tumor patients. Concentration of Cd was determined in breast tissue, urine, and blood of 57 breast cancer and 51 benign tumor patients. Two samples of breast tissue from each patient, i.e., tumor and healthy tissue were taken for the analysis. Cd in biological media was determined by atomic absorption spectrometry (Perkin-Elmer, Zeeman 3030). The mean Cd concentration in breast cancer patients was 0.053 μg/g (95% confidence intervals, CI 0.042-0.065) for tumor sample and 0.02 μg/g (95% CI 0.014-0.026) for healthy breast tissue sample (P < 0.001). In benign tumor patients, the figures were as follows: 0.037 μg/g (95% CI 0.023-0.051) and 0.032 μg/g (95% CI 0.018-0.047) (P > 0.05). Cd content in malignant tumor significantly differed from that in benign tumor (P < 0.01). Cancer patients with positive estrogen receptors (ERs) had significantly greater concentration of breast tissue Cd compared to patients with negative ERs (P = 0.035). Adjusted for creatinine, Cd in urine was significantly higher in cancer patients than in controls (P < 0.001). In cancer patients, a positive Spearman's correlation was found between Cd in tumor and healthy breast tissue, blood (r = 0.44 and r = 0.39, respectively, P < 0.01). Correlation between Cd in urine of cancer patients and number of cigarettes smoked during lifetime was suggestive (r = 0.59, P = 0.075). The data obtained show higher concentration of cadmium in breast tumor and urine of cancer patients and support a possible relationship between cadmium and breast cancer.
本研究旨在测定并比较乳腺癌和良性乳腺肿瘤患者不同生物介质中的镉（Cd）浓度。 对 57 例乳腺癌和 51 例良性肿瘤患者的乳腺组织、尿液和血液中的 Cd 浓度进行了测定。 从每位患者中取两份乳腺组织样本，即肿瘤和健康组织样本用于分析。 采用原子吸收光谱法（Perkin-Elmer，Zeeman 3030）测定生物介质中的 Cd。 乳腺癌患者肿瘤组织样本中的 Cd 平均浓度为 0.053μg/g（95%置信区间，CI 0.042-0.065），健康乳腺组织样本为 0.02μg/g（95%CI 0.014-0.026）（P<0.001）。 在良性肿瘤患者中，结果分别为 0.037μg/g（95%CI 0.023-0.051）和 0.032μg/g（95%CI 0.018-0.047）（P>0.05）。 恶性肿瘤的 Cd 含量与良性肿瘤显著不同（P<0.01）。 雌激素受体（ERs）阳性的癌症患者的乳腺组织 Cd 浓度明显高于 ERs 阴性的患者（P=0.035）。 校正肌酐后，癌症患者尿液中的 Cd 浓度明显高于对照组（P<0.001）。 在癌症患者中，肿瘤和健康乳腺组织以及血液中的 Cd 之间呈正 Spearman 相关（r=0.44 和 r=0.39，P<0.01）。 癌症患者尿液中的 Cd 与终生吸烟数量之间存在提示性相关性（r=0.59，P=0.075）。 所得数据显示乳腺癌患者的乳腺肿瘤和尿液中 Cd 浓度较高，支持 Cd 与乳腺癌之间可能存在关系。
