Aurora Health Care, Milwaukee, Wisconsin, USA.
Am J Perinatol. 2011 Jan;28(1):45-50. doi: 10.1055/s-0030-1262510. Epub 2010 Jul 6.
The purpose of the review article is to determine if prolonged (≥48 hour) tocolytics with symptomatic preterm placenta previa improves perinatal outcome. OVID MEDLINE and Cochrane Databases were searched from January 1950 to January 2009. Odds ratio (OR) and 95% confidence intervals (CI) were calculated. We identified two retrospective studies ( N = 217) and one randomized clinical trial (RCT; N = 60), and they were analyzed separately. Results of the RCT indicated that pregnancy is prolonged for more than 7 days with continued tocolytics (OR 3.10, 95% CI 1.38 to 6.96) but combined results of two retrospective studies did not confirm the prolongation (OR 1.19, 95% CI 0.63 to 2.28). The RCT was inadequately compliant with Consolidated Standards of Reporting Trials statement. While awaiting an appropriately designed RCT to determine the duration of tocolytics with placenta previa and preterm labor, it should be limited to 48 hours.
这篇综述文章的目的是确定延长（≥48 小时）宫缩抑制剂治疗症状性前置胎盘伴早产是否能改善围产结局。我们检索了 OVID MEDLINE 和 Cochrane 数据库，检索时间从 1950 年 1 月到 2009 年 1 月。计算了比值比（OR）和 95%置信区间（CI）。我们共发现两项回顾性研究（N=217）和一项随机临床试验（RCT；N=60），并分别进行了分析。RCT 的结果表明，继续使用宫缩抑制剂会使妊娠延长超过 7 天（OR 3.10，95%CI 1.38 至 6.96），但两项回顾性研究的综合结果并未证实妊娠延长（OR 1.19，95%CI 0.63 至 2.28）。RCT 没有充分遵守报告临床试验的统一标准。在等待设计合理的 RCT 来确定前置胎盘伴早产的宫缩抑制剂使用时间之前，应将其限制在 48 小时内。
