Cote T E, Yasumura S
Acta Endocrinol (Copenh). 1978 Apr;87(4):811-9. doi: 10.1530/acta.0.0870811.
In 2 to 16-day-old rats subjected to heat, the adrenal content of cAMP did not increase in animals younger than 14 days of age, but serum corticosterone was significantly higher than control values at all ages except in 10 and 12-day-old animals. This would suggest that cAMP may not mediate the adrenal steroidogenic response to stress during the first post-natal week. This hypothesis is consistent with the fact that the administration of 0.195 and 0.785 mU ACTH to 2-day-old rats resulted in a significant increase in serum corticosterone without a rise in the adrenal content of cAMP. The stress-induced rise in serum corticosterone progressively diminishes during the first post-natal week before returning to its previous 2-day-old capacity by day 16.
在2至16日龄遭受热应激的大鼠中，14日龄以下动物的肾上腺环磷酸腺苷（cAMP）含量未增加，但除10日龄和12日龄动物外，所有年龄段的血清皮质酮均显著高于对照值。这表明在出生后的第一周，cAMP可能不介导肾上腺对压力的类固醇生成反应。这一假设与以下事实一致：给2日龄大鼠注射0.195和0.785 mU促肾上腺皮质激素（ACTH）会导致血清皮质酮显著增加，而肾上腺cAMP含量并未升高。在出生后的第一周，应激诱导的血清皮质酮升高会逐渐减弱，到第16天恢复到之前2日龄时的水平。
