Cote T E, Yasumura S
Endocrinology. 1975 Apr;96(4):1044-7. doi: 10.1210/endo-96-4-1044.
Adrenal cAMP and plasma corticosterone levels were determined in pre-weanling rats subjected to treatment with either ACTH (50 mU/rat) or histamine dihydrochloride (0.2 mg/g body wt). ACTH injection elevated both serum corticosterone and adrenal cAMP levels on all days tested. However, the ACTH-induced elevation of adrenal cAMP and serum corticosterone both diminished steadily from day 2 to day 8 and then increased from day 8 to day 16. Histamine injection resulted in elevated serum corticosterone levels in a pattern similar to that of the corticosterone response to ACTH. However, histamine injection did not result in any significant increase in adrenal cAMP from day 2 to day 10. From day 12 to day 16 the adrenal cAMP concentration rose steadily in parallel with ther serum corticosterone levels. These results indicate: (1) that a functional, ACTH-sensitive adenyl cyclase system is present in the adrenal gland of the immature rat, (2) that the responsiveness of this system diminishes during the first postnatal week before returning to its previous 2-day-old capacity by day 16, and (3) that during the first few days after birth, histamine stress results in elevated serum corticosterone levels without elevating adrenal cAMP levels.
对断奶前大鼠分别用促肾上腺皮质激素（50 mU/只大鼠）或二盐酸组胺（0.2 mg/g体重）进行处理，然后测定其肾上腺环磷酸腺苷（cAMP）水平和血浆皮质酮水平。在所有测试日，注射促肾上腺皮质激素均使血清皮质酮和肾上腺cAMP水平升高。然而，促肾上腺皮质激素诱导的肾上腺cAMP和血清皮质酮升高在第2天至第8天稳步下降，然后在第8天至第16天又升高。注射组胺导致血清皮质酮水平升高，其模式与皮质酮对促肾上腺皮质激素的反应相似。然而，从第2天到第10天，注射组胺并未导致肾上腺cAMP有任何显著增加。从第12天到第16天，肾上腺cAMP浓度与血清皮质酮水平平行稳步上升。这些结果表明：（1）未成熟大鼠的肾上腺中存在一个功能性的、对促肾上腺皮质激素敏感的腺苷酸环化酶系统；（2）该系统的反应性在出生后的第一周内降低，到第16天恢复到其出生前两天的水平；（3）在出生后的头几天，组胺应激导致血清皮质酮水平升高，但不导致肾上腺cAMP水平升高。
