Pons L, Droy-Lefaix M T, Braquet P, Buéno L
Department of Pharmacology INRA, Toulouse, France.
Free Radic Res Commun. 1991;12-13 Pt 2:629-32. doi: 10.3109/10715769109145839.
Pretreatment with radical scavengers significantly reduced the intestinal myoelectric disturbances following either E. coli endotoxin or platelet-activating factor (PAF) injection in the rat indicating that free radicals might be involved in the intestinal motor alterations observed in endotoxin shock and that PAF acts partially via free radical production. Moreover, dimethylsulfoxide (DMSO) was found to be more effective in inhibiting the endoxotin-induced intestinal motor alterations, than superoxide dismutase (SOD) and allopurinol. BN 52021, a specific PAF antagonist, was able to reduce the effects of endotoxin on intestinal motility. However, when BN 52021 was combined with free radical scavengers, no additive effect was observed. It is concluded that free radicals involved in endotoxin-induced intestinal motility alterations are at least in part produced in response to PAF.
在大鼠中，用自由基清除剂进行预处理可显著减轻大肠杆菌内毒素或血小板活化因子（PAF）注射后出现的肠道肌电紊乱，这表明自由基可能参与了内毒素休克时观察到的肠道运动改变，且PAF部分通过自由基生成发挥作用。此外，发现二甲基亚砜（DMSO）在抑制内毒素诱导的肠道运动改变方面比超氧化物歧化酶（SOD）和别嘌呤醇更有效。BN 52021是一种特异性PAF拮抗剂，能够减轻内毒素对肠道运动的影响。然而，当BN 52021与自由基清除剂联合使用时，未观察到相加效应。得出的结论是，内毒素诱导的肠道运动改变中涉及的自由基至少部分是对PAF的反应而产生的。
