Etienne A, Thonier F, Braquet P
Institut Henri Beaufour Research Laboratories, Les Ulis, France.
Int J Tissue React. 1989;11(2):59-64.
Platelet-activating factor (PAF) has been shown to induce gastro-intestinal damage similar to that evoked by endotoxin, suggesting that this mediator may be involved in the formation of gastrointestinal lesions observed in various pathologies. Thus, the effects of BN 52021, a specific PAF antagonist, were investigated in several experimental models of gastro-intestinal damage in rats. BN 52021 markedly reduced the gastric alterations and almost totally abolished the intestinal lesions induced by PAF. Similarly, BN 52021 reduced gastro-intestinal damage induced by endotoxin, but it afforded less protection against endotoxin-induced changes than those caused by PAF. This difference is probably due to the multicomponent activating effect of endotoxin. In the cold restraint stress model, BN 52021 decreased both gastro-intestinal lesions and the change in plasma transaminase level. The results presented in this paper confirm the role of PAF in gastro-intestinal damage induced by endotoxin but also suggest the involvement of this mediator in stress-induced lesions. PAF-antagonists could thus be of therapeutic use in such pathologies.
血小板活化因子（PAF）已被证明可诱发类似于内毒素所引起的胃肠道损伤，这表明该介质可能参与了在各种病理状态下所观察到的胃肠道病变的形成。因此，在大鼠胃肠道损伤的多个实验模型中研究了特异性PAF拮抗剂BN 52021的作用。BN 52021显著减轻了胃部病变，并几乎完全消除了PAF诱导的肠道病变。同样，BN 52021减轻了内毒素诱导的胃肠道损伤，但与PAF所引起的损伤相比，它对内毒素诱导的变化提供的保护较少。这种差异可能是由于内毒素的多组分激活作用。在冷束缚应激模型中，BN 52021减少了胃肠道病变以及血浆转氨酶水平的变化。本文给出的结果证实了PAF在内毒素诱导的胃肠道损伤中的作用，但也表明该介质参与了应激诱导的病变。因此，PAF拮抗剂在这类病症中可能具有治疗用途。
