Houze P, Rouach H, Gentil M, Orfanelli M T, Nordmann R
Department of Biomedical Research on Alcoholism, University René Descartes, Paris, France.
Free Radic Res Commun. 1991;12-13 Pt 2:663-8. doi: 10.3109/10715769109145844.
An acute ethanol load (50 mmol/kg, i.p.) induces an increase in the total non-heme iron and in the low-molecular-weight non-heme iron complexes (LMW-Fe) content both in liver and cerebellum. This increase in LMW-Fe is associated with a decrease in some essential trace elements (selenium, zinc, copper) playing a role in the anti-oxidant system. These changes could contribute to the enhancement in lipid peroxidation which occurs at the hepatic and cerebellar level following the ethanol administration. The administration of allopurinol prior to the ethanol load prevents the changes in non-heme iron and trace elements. This prevention may contribute to the protective effects of allopurinol on the ethanol-induced oxidative stress.
急性乙醇负荷（50 mmol/kg，腹腔注射）可导致肝脏和小脑的总非血红素铁以及低分子量非血红素铁复合物（LMW-Fe）含量增加。LMW-Fe的这种增加与抗氧化系统中一些必需微量元素（硒、锌、铜）的减少有关。这些变化可能导致乙醇给药后肝脏和小脑脂质过氧化增强。在乙醇负荷前给予别嘌呤醇可防止非血红素铁和微量元素的变化。这种预防作用可能有助于别嘌呤醇对乙醇诱导的氧化应激的保护作用。
