Rouach H, Houzé P, Park M, Nordmann R
Département de Recherches Biomédicales sur l'Alcoolisme, Université René-Descartes, Paris.
C R Seances Soc Biol Fil. 1989;183(1):40-7.
An acute ethanol load results in an increased total nonheme iron and cytosolic low molecular weight iron content in rat cerebellum. At the same time the cerebellar susceptibility to lipid peroxidation is enhanced whereas the alpha-tocopherol and ascorbate content is decreased. These changes argue for a cerebellar ethanol-induced oxidative stress, which is prevented by prior allopurinol administration.
急性乙醇负荷会导致大鼠小脑总非血红素铁和胞质低分子量铁含量增加。与此同时，小脑对脂质过氧化的敏感性增强，而α-生育酚和抗坏血酸含量降低。这些变化表明存在小脑乙醇诱导的氧化应激，预先给予别嘌呤醇可预防这种应激。
