Department of Chemistry, Iowa State University, Ames, Iowa 50011, United States.
J Org Chem. 2012 Oct 5;77(19):8648-56. doi: 10.1021/jo3016192. Epub 2012 Sep 26.
The palladium-catalyzed annulation of arynes by substituted o-halobenzamides produces N-substituted phenanthridinones in good yields. This methodology provides this important heterocyclic ring system in a single step by simultaneous C-C and C-N bond formation, under relatively mild reaction conditions, and tolerates a variety of functional groups.
钯催化的芳炔与取代的邻卤代苯甲酰胺的环化反应以良好的收率生成了 N-取代的菲啶酮。该方法在相对温和的反应条件下，通过同时形成 C-C 和 C-N 键，以一步法提供了这种重要的杂环体系，并能耐受多种官能团。
