银屑病患者血清催乳素水平及其与皮肤疾病活动度的相关性。
Serum prolactin levels in psoriasis and correlation with cutaneous disease activity.
机构信息
Department of Dermatology, Sagrat Cor University Hospital, Barcelona, Spain.
出版信息
Clin Exp Dermatol. 2011 Jan;36(1):29-32. doi: 10.1111/j.1365-2230.2010.03871.x.
BACKGROUND
Prolactin (PRL), a neuropeptide secreted by the anterior pituitary gland, possesses a variety of physiological actions. It has been implicated as an important immunomodulator and exerts a proliferative effect in cultured human keratinocytes via specific receptors. Some studies have indicated an increase in serum PRL levels in psoriasis and exacerbation of psoriasis when a prolactinoma is present.
AIM
To evaluate the correlation between serum PRL levels and Psoriasis Area and Severity Index (PASI).
METHODS
Serum PRL levels were measured in 20 patients (10 mean, 10 women, age range 18-88 years) with plaque-type psoriasis before and after a 6-week period of topical treatment with tacalcitol ointment. Results were compared with a group of 20 healthy volunteers.
RESULTS
Serum PRL levels were significantly increased in the psoriatic group compared with the control group (P < 0.001) and were significantly reduced after treatment (P = 0.001). There was a correlation between pretreatment serum PRL levels and PASI (r = 0.33; P = 0.02).
CONCLUSIONS
These results indicate that serum PRL levels may serve as a biological marker of psoriatic disease activity.
背景
催乳素（PRL）是一种由垂体前叶分泌的神经肽，具有多种生理作用。它已被认为是一种重要的免疫调节剂，并通过特异性受体在培养的人角质形成细胞中发挥增殖作用。一些研究表明，在银屑病中血清 PRL 水平升高，当存在催乳素瘤时银屑病会恶化。
目的
评估血清 PRL 水平与银屑病面积和严重程度指数（PASI）之间的相关性。
方法
在 20 例斑块型银屑病患者（10 例男性，10 例女性，年龄 18-88 岁）接受他卡西醇软膏治疗 6 周前后测量血清 PRL 水平。将结果与 20 名健康志愿者进行比较。
结果
与对照组相比，银屑病组血清 PRL 水平显著升高（P<0.001），治疗后显著降低（P=0.001）。治疗前血清 PRL 水平与 PASI 之间存在相关性（r=0.33；P=0.02）。
结论
这些结果表明，血清 PRL 水平可能是银屑病疾病活动的生物标志物。
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