Department of General Biology and Genetics, Third Faculty of Medicine, Charles University in Prague, Ruska 87, 10000 Prague 10, Czech Republic.
Rheumatol Int. 2013 Apr;33(4):913-9. doi: 10.1007/s00296-012-2472-7. Epub 2012 Jul 22.
Psoriatic arthritis (PsA) affects approximately 30 % of patients suffering from psoriasis vulgaris (PsV), but the risk factors for its development have not been well elucidated yet. The HLA-Cw06 allele was described as a predisposing factor to PsV. Prolactin is known as an immune response modulator, and its elevated levels present risk for PsV development. It is possible that these factors interact and together emphasize the predisposition to both diseases. We tested on an association of HLA-Cw alleles and functional polymorphism -1149 G/T in PRL gene extrapituitary promoter with PsV and PsA in Czech population. We found a statistically significant association between HLA-Cw06 allele and PsV (P corrected = 0.0013) that was most prominent in early onset disease subtype (P corrected = 0.0013). The association between HLA-Cw*06 and PsA was low (P corrected = 0.0585) and restricted to PsA patients with early PsV onset (P corrected = 0.0195). We found no association of -1149 G/T PRL gene polymorphism with either PsV or PsA.
银屑病关节炎（PsA）影响约 30%患有寻常型银屑病（PsV）的患者，但其发病的危险因素尚未得到充分阐明。HLA-Cw06 等位基因被描述为 PsV 的易患因素。催乳素是已知的免疫反应调节剂，其水平升高会增加 PsV 发病的风险。这些因素可能相互作用，并共同强调对这两种疾病的易感性。我们在捷克人群中测试了 HLA-Cw 等位基因和催乳素基因外显子启动子中的功能性多态性-1149G/T 与 PsV 和 PsA 的关联。我们发现 HLA-Cw06 等位基因与 PsV 之间存在统计学显著关联（P 校正=0.0013），在疾病早期发病亚型中最为显著（P 校正=0.0013）。HLA-Cw*06 与 PsA 的相关性较低（P 校正=0.0585），且仅限于 PsA 患者中 PsV 发病较早的患者（P 校正=0.0195）。我们未发现 -1149G/T 催乳素基因多态性与 PsV 或 PsA 相关。
