Department of Dermatology Royal Hospitals Trust, Belfast, UK.
Clin Exp Dermatol. 2011 Mar;36(2):201-3. doi: 10.1111/j.1365-2230.2010.03949.x. Epub 2010 Nov 10.
A reliable biomarker of disease activity in psoriasis would be helpful for management, especially if this gave early information on treatment efficacy. This study investigated whether serum levels of soluble (s)CD163 correlated with psoriasis activity as assessed by the Psoriasis Area and Severity Index (PASI). CD163, a glycoprotein molecule expressed on macrophages and dendritic cells, is cleaved from the surface of these cells in some inflammatory diseases, and sCD163 levels have been shown to correlate with disease activity in other disorders. In this study, levels of sCD163 did not correlate with PASI in the patients (P = 0.56). Five patients had moderately increased PASI (12.6-20.3) but their sCD163 levels were within the normal range. From this study, it seems that sCD163 levels do not correlate with the inflammatory process in the skin of patients with psoriasis and thus sCD163 is not likely to be a useful biomarker for this disease.
一种可靠的银屑病疾病活动生物标志物将有助于治疗管理，特别是如果它能提供有关治疗效果的早期信息。本研究调查了可溶性 (s)CD163 血清水平是否与银屑病面积和严重程度指数 (PASI) 评估的银屑病活动相关。CD163 是一种在巨噬细胞和树突状细胞上表达的糖蛋白分子，在某些炎症性疾病中从这些细胞表面被切割，并且 sCD163 水平与其他疾病中的疾病活动相关。在这项研究中，sCD163 水平与患者的 PASI 没有相关性（P = 0.56）。五名患者的 PASI 中度升高（12.6-20.3），但他们的 sCD163 水平在正常范围内。从这项研究中可以看出，sCD163 水平与银屑病患者皮肤的炎症过程似乎没有相关性，因此 sCD163 不太可能成为这种疾病的有用生物标志物。
