根据酒精摄入量选择的大鼠品系中的尿中环磷酸腺苷和抗利尿激素排泄量

Urinary cyclic AMP and vasopressin excretion in rat strains selected for their alcohol intake.

作者信息

Linkola J, Fyhrquist F

出版信息

Acta Physiol Scand. 1978 Mar;102(3):364-7. doi: 10.1111/j.1748-1716.1978.tb06083.x.

DOI:10.1111/j.1748-1716.1978.tb06083.x

PMID:206097

Abstract

Urinary excretion of adenosine 3',5' -cyclic monophosphate (cAMP) and immunoreactive arginine vasopressin (AVP) were investigated after water loading and following ethanol loading in two rat strains selected for their voluntary ethanol intake. After ethanol loading ethanol preferring (AA) rats excreted more cAMP but less AVP than water preferring (ANA) rats. The results suggest that the strain difference in cAMP excretion is of renal origin and is not due to vasopressin or parathormone. Differences in the sympathetic nervous activity may be responsible for the difference in cAMP excretion.

摘要

对两种因自愿乙醇摄入量不同而挑选出的大鼠品系，在水负荷和乙醇负荷后，研究了3',5'-环磷酸腺苷（cAMP）的尿排泄和免疫反应性精氨酸加压素（AVP）。乙醇负荷后，乙醇偏好型（AA）大鼠比水偏好型（ANA）大鼠排泄更多的cAMP，但AVP较少。结果表明，cAMP排泄的品系差异源于肾脏，并非由加压素或甲状旁腺激素引起。交感神经活动的差异可能是cAMP排泄差异的原因。