Kohnen Thomas, Klaproth Oliver K
Department of Ophthalmology, Goethe-University, Frankfurt am Main, Germany.
J Cataract Refract Surg. 2010 Jul;36(7):1120-6. doi: 10.1016/j.jcrs.2010.01.023.
To examine the postoperative positional stability of a new angle-supported, hydrophobic acrylic phakic intraocular lens (pIOL).
Department of Ophthalmology, Goethe-University, Frankfurt am Main, Germany.
In this prospective nonrandomized clinical trial, eyes with moderate to high myopia had implantation of an angle-supported pIOL (AcrySof Cachet). Scheimpflug imaging was performed preoperatively and postoperatively at 1, 3, 6 to 12, and 24 to 36 months. The main outcome measures were the distance between the corneal endothelium and the IOL and between the IOL and the crystalline lens. The overall significance threshold was P = .05.
Twenty-one of the 26 eyes (26 patients) evaluated were included in the statistical analysis. Analysis of variance showed no statistically significant differences in absolute endothelium-IOL or IOL-crystalline lens measurements at any postoperative visit. The mean endothelium-IOL distance was 2.05 mm +/- 0.25 (SD) at 1 month and 2.15 +/- 0.29 mm at 24 to 36 months and the mean IOL-crystalline distance, 0.92 +/- 0.23 mm and 0.86 +/- 0.22 mm, respectively. A 1-way t test showed a small but significant difference compared with zero in the overall change in the endothelium-IOL distance (mean 0.08 +/- 0.16 mm) and thus in the overall calculated anterior chamber depth (mean 0.07 +/- 0.08 mm); the difference was not significant for the IOL-crystalline lens change (mean -0.05 +/- 0.13 mm).
The angle-supported foldable hydrophobic pIOL maintained adequate central clearance distances to the corneal endothelium and the natural crystalline lens over 3 years.
Neither author has a financial or proprietary interest in any material or method mentioned. Additional disclosure is found in the footnotes.
研究一种新型角支撑、疏水性丙烯酸人工晶状体（pIOL）术后的位置稳定性。
德国美因河畔法兰克福歌德大学眼科。
在这项前瞻性非随机临床试验中，中高度近视患者植入角支撑pIOL（AcrySof Cachet）。术前以及术后1、3、6至12个月和24至36个月进行Scheimpflug成像。主要观察指标为角膜内皮与人工晶状体之间以及人工晶状体与晶状体之间的距离。总体显著性阈值为P = 0.05。
评估的26只眼（26例患者）中的21只纳入统计分析。方差分析显示，术后任何随访时，角膜内皮与人工晶状体或人工晶状体与晶状体的绝对测量值均无统计学显著差异。角膜内皮与人工晶状体的平均距离在1个月时为2.05 mm±0.25（标准差），在24至36个月时为2.15±0.29 mm；人工晶状体与晶状体的平均距离分别为0.92±0.23 mm和0.86±0.22 mm。单样本t检验显示，角膜内皮与人工晶状体距离的总体变化（平均0.08±0.16 mm）与零相比有微小但显著的差异，因此总体计算的前房深度（平均0.07±0.08 mm）也有差异；人工晶状体与晶状体距离的变化（平均 -0.05±0.13 mm）差异不显著。
角支撑可折叠疏水性人工晶状体在3年多的时间里与角膜内皮和天然晶状体保持了足够的中央间隙距离。
两位作者均对文中提及的任何材料或方法无财务或所有权权益。其他披露信息见脚注。
