Philips Research, Minimally Invasive Healthcare Department, 5656 AE Eindhoven, The Netherlands.
J Biomed Opt. 2010 May-Jun;15(3):037015. doi: 10.1117/1.3454392.
We demonstrate a method to estimate the concentrations of water and lipid in scattering media such as biological tissues with diffuse optical spectra acquired over the range of 900 to 1600 nm. Estimations were performed by fitting the spectra to a model of light propagation in scattering media derived from diffusion theory. To validate the method, spectra were acquired from tissue phantoms consisting of lipid and water emulsions and swine tissues ex vivo with a two-fiber probe.
我们展示了一种方法，可以通过在 900 到 1600nm 范围内采集的漫射光光谱来估计散射介质（如生物组织）中的水和脂质浓度。通过将光谱拟合到从扩散理论推导出来的散射介质中光传播模型来进行估计。为了验证该方法，使用双光纤探头从由脂质和水乳液组成的组织模型以及离体猪组织中采集了光谱。
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