Greatwall kinase protects mitotic phosphosites from barbarian phosphatases.
作者信息
Goldberg Michael L
机构信息
Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA.
出版信息
Proc Natl Acad Sci U S A. 2010 Jul 13;107(28):12409-10. doi: 10.1073/pnas.1006046107. Epub 2010 Jun 30.
Abstract
摘要
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Greatwall kinase protects mitotic phosphosites from barbarian phosphatases.长城激酶保护有丝分裂磷酸位点免受野蛮磷酸酶的作用。
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Greatwall and Polo-like kinase 1 coordinate to promote checkpoint recovery.长城激酶和 Polo 样激酶 1 协调促进检查点恢复。
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本文引用的文献
1
Loss of human Greatwall results in G2 arrest and multiple mitotic defects due to deregulation of the cyclin B-Cdc2/PP2A balance.由于细胞周期蛋白 B-Cdc2/PP2A 平衡失调，人类 GWAS 缺失导致 G2 期阻滞和多种有丝分裂缺陷。
Proc Natl Acad Sci U S A. 2010 Jul 13;107(28):12564-9. doi: 10.1073/pnas.0914191107. Epub 2010 Jun 10.
2
The M phase kinase Greatwall (Gwl) promotes inactivation of PP2A/B55delta, a phosphatase directed against CDK phosphosites.M 期激酶 Greatwall（Gwl）促进了针对 CDK 磷酸化位点的磷酸酶 PP2A/B55delta 的失活。
Mol Biol Cell. 2009 Nov;20(22):4777-89. doi: 10.1091/mbc.e09-07-0643. Epub 2009 Sep 30.
3
Regulated activity of PP2A-B55 delta is crucial for controlling entry into and exit from mitosis in Xenopus egg extracts.PP2A-B55δ 的调控活性对于控制非洲爪蟾卵提取物中细胞有丝分裂的进出至关重要。
EMBO J. 2009 Sep 16;28(18):2777-85. doi: 10.1038/emboj.2009.238. Epub 2009 Aug 20.
4
Greatwall maintains mitosis through regulation of PP2A.长城通过调节蛋白磷酸酶2A维持有丝分裂。
EMBO J. 2009 Sep 16;28(18):2786-93. doi: 10.1038/emboj.2009.228. Epub 2009 Aug 13.
5
PP1-mediated dephosphorylation of phosphoproteins at mitotic exit is controlled by inhibitor-1 and PP1 phosphorylation.PP1介导的有丝分裂退出时磷酸化蛋白的去磷酸化受抑制剂-1和PP1磷酸化的控制。
Nat Cell Biol. 2009 May;11(5):644-51. doi: 10.1038/ncb1871. Epub 2009 Apr 26.
6
Cdk-counteracting phosphatases unlock mitotic exit.细胞周期蛋白依赖性激酶拮抗磷酸酶开启有丝分裂退出。
Curr Opin Cell Biol. 2008 Dec;20(6):661-8. doi: 10.1016/j.ceb.2008.09.003. Epub 2008 Oct 22.
7
Roles of Greatwall kinase in the regulation of cdc25 phosphatase.长城激酶在细胞分裂周期蛋白25磷酸酶调节中的作用。
Mol Biol Cell. 2008 Apr;19(4):1317-27. doi: 10.1091/mbc.e07-11-1099. Epub 2008 Jan 16.
8
Mutations in Drosophila Greatwall/Scant reveal its roles in mitosis and meiosis and interdependence with Polo kinase.果蝇Greatwall/Scant基因的突变揭示了其在有丝分裂和减数分裂中的作用以及与Polo激酶的相互依赖性。
PLoS Genet. 2007 Nov;3(11):e200. doi: 10.1371/journal.pgen.0030200.
9
Calcineurin is required to release Xenopus egg extracts from meiotic M phase.钙调神经磷酸酶是使非洲爪蟾卵提取物从减数分裂M期释放所必需的。
Nature. 2007 Sep 20;449(7160):336-40. doi: 10.1038/nature06121.
10
Greatwall kinase participates in the Cdc2 autoregulatory loop in Xenopus egg extracts.长城激酶参与非洲爪蟾卵提取物中的Cdc2自动调节环。
Mol Cell. 2006 Apr 7;22(1):83-91. doi: 10.1016/j.molcel.2006.02.022.
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