细胞周期蛋白A、细胞分裂周期蛋白25+有丝分裂诱导剂和2A型磷酸酶在G2/M期转换时激活细胞周期蛋白B/细胞分裂周期蛋白2激酶中的协同作用。 - Suppr

Concerted roles of cyclin A, cdc25+ mitotic inducer, and type 2A phosphatase in activating the cyclin B/cdc2 protein kinase at the G2/M phase transition.

作者信息

Devault A, Cavadore J C, Fesquet D, Labbé J C, Lorca T, Picard A, Strausfeld U, Dorée M

机构信息

Centre National de la Recherche Scientifique et Institut National de la Santé et de la Recherche Médicale, Montpellier, France.

出版信息

Cold Spring Harb Symp Quant Biol. 1991;56:503-13. doi: 10.1101/sqb.1991.056.01.057.

DOI:10.1101/sqb.1991.056.01.057

PMID:1668088

Abstract

摘要

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Concerted roles of cyclin A, cdc25+ mitotic inducer, and type 2A phosphatase in activating the cyclin B/cdc2 protein kinase at the G2/M phase transition.细胞周期蛋白A、细胞分裂周期蛋白25+有丝分裂诱导剂和2A型磷酸酶在G2/M期转换时激活细胞周期蛋白B/细胞分裂周期蛋白2激酶中的协同作用。

Cold Spring Harb Symp Quant Biol. 1991;56:503-13. doi: 10.1101/sqb.1991.056.01.057.

Phosphorylation and activation of the Xenopus Cdc25 phosphatase in the absence of Cdc2 and Cdk2 kinase activity.非洲爪蟾Cdc25磷酸酶在缺乏Cdc2和Cdk2激酶活性时的磷酸化与激活

Mol Biol Cell. 1995 Feb;6(2):215-26. doi: 10.1091/mbc.6.2.215.

Elimination of cdc2 phosphorylation sites in the cdc25 phosphatase blocks initiation of M-phase.消除细胞分裂周期蛋白25磷酸酶（cdc25 phosphatase）中的细胞分裂周期蛋白2（cdc2）磷酸化位点会阻断M期的起始。

Mol Biol Cell. 1993 Dec;4(12):1337-50. doi: 10.1091/mbc.4.12.1337.

Oscillation of MPF is accompanied by periodic association between cdc25 and cdc2-cyclin B.MPF的振荡伴随着cdc25与cdc2-细胞周期蛋白B之间的周期性结合。

Cell. 1992 Jan 24;68(2):323-32. doi: 10.1016/0092-8674(92)90473-p.

Periodic changes in phosphorylation of the Xenopus cdc25 phosphatase regulate its activity.非洲爪蟾cdc25磷酸酶磷酸化的周期性变化调节其活性。

Mol Biol Cell. 1992 Aug;3(8):927-39. doi: 10.1091/mbc.3.8.927.

Phosphorylation and activation of human cdc25-C by cdc2--cyclin B and its involvement in the self-amplification of MPF at mitosis.细胞周期蛋白依赖性激酶2（cdc2）-细胞周期蛋白B对人细胞周期蛋白磷酸酶25-C（cdc25-C）的磷酸化及激活作用，及其在有丝分裂期促成熟因子（MPF）自我放大过程中的作用。

EMBO J. 1993 Jan;12(1):53-63. doi: 10.1002/j.1460-2075.1993.tb05631.x.

A role for cAMP-dependent protein kinase in early embryonic divisions.

Proc Natl Acad Sci U S A. 1994 Oct 11;91(21):9896-900. doi: 10.1073/pnas.91.21.9896.

Cyclin A potentiates maturation-promoting factor activation in the early Xenopus embryo via inhibition of the tyrosine kinase that phosphorylates cdc2.细胞周期蛋白A通过抑制使cdc2磷酸化的酪氨酸激酶，增强非洲爪蟾早期胚胎中促成熟因子的激活作用。

J Cell Biol. 1992 Sep;118(5):1109-20. doi: 10.1083/jcb.118.5.1109.

Okadaic acid mimics a nuclear component required for cyclin B-cdc2 kinase microinjection to drive starfish oocytes into M phase.冈田酸模拟了细胞周期蛋白B-细胞分裂周期蛋白2激酶显微注射驱动海星卵母细胞进入M期所需的一种核成分。

J Cell Biol. 1991 Oct;115(2):337-44. doi: 10.1083/jcb.115.2.337.

cdc25 is one of the MPM-2 antigens involved in the activation of maturation-promoting factor.细胞分裂周期蛋白25（cdc25）是参与成熟促进因子激活的MPM-2抗原之一。

Mol Biol Cell. 1994 Feb;5(2):135-45. doi: 10.1091/mbc.5.2.135.

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Chamaejasmine arrests cell cycle, induces apoptosis and inhibits nuclear NF-κB translocation in the human breast cancer cell line MDA-MB-231.栀子抑制人乳腺癌 MDA-MB-231 细胞周期、诱导细胞凋亡和核 NF-κB 易位。

Molecules. 2013 Jan 11;18(1):845-58. doi: 10.3390/molecules18010845.

In vitro and in vivo effects of water extract of white cocoa tea (Camellia ptilophylla) against human prostate cancer.白可可茶（Camellia ptilophylla）水提取物对人前列腺癌的体内外作用。

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Growth inhibitory effects of dihydroartemisinin on pancreatic cancer cells: involvement of cell cycle arrest and inactivation of nuclear factor-kappaB.双氢青蒿素对胰腺癌细胞的生长抑制作用：涉及细胞周期停滞和核因子-κB 的失活。

J Cancer Res Clin Oncol. 2010 Jun;136(6):897-903. doi: 10.1007/s00432-009-0731-0. Epub 2009 Nov 26.

Delphinidin, a dietary anthocyanidin in pigmented fruits and vegetables: a new weapon to blunt prostate cancer growth.飞燕草素，一种存在于有色水果和蔬菜中的膳食花青素：抑制前列腺癌生长的新武器。

Cell Cycle. 2008 Nov 1;7(21):3320-6. doi: 10.4161/cc.7.21.6969. Epub 2008 Nov 9.

A dietary anthocyanidin delphinidin induces apoptosis of human prostate cancer PC3 cells in vitro and in vivo: involvement of nuclear factor-kappaB signaling.膳食花青素飞燕草色素在体外和体内均可诱导人前列腺癌PC3细胞凋亡：与核因子-κB信号通路有关。

Cancer Res. 2008 Oct 15;68(20):8564-72. doi: 10.1158/0008-5472.CAN-08-2232.

Mitogen-activated protein kinase activation down-regulates a mechanism that inactivates cyclin B-cdc2 kinase in G2-arrested oocytes.丝裂原活化蛋白激酶的激活下调了一种在G2期阻滞的卵母细胞中使细胞周期蛋白B - cdc2激酶失活的机制。

Mol Biol Cell. 1997 Feb;8(2):249-61. doi: 10.1091/mbc.8.2.249.

The MO15 gene encodes the catalytic subunit of a protein kinase that activates cdc2 and other cyclin-dependent kinases (CDKs) through phosphorylation of Thr161 and its homologues.MO15基因编码一种蛋白激酶的催化亚基，该蛋白激酶通过对苏氨酸161及其同源物进行磷酸化来激活cdc2和其他细胞周期蛋白依赖性激酶（CDK）。

EMBO J. 1993 Aug;12(8):3111-21. doi: 10.1002/j.1460-2075.1993.tb05980.x.

J Cell Biol. 1992 Sep;118(5):1109-20. doi: 10.1083/jcb.118.5.1109.

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Concerted roles of cyclin A, cdc25+ mitotic inducer, and type 2A phosphatase in activating the cyclin B/cdc2 protein kinase at the G2/M phase transition.

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