Department of Medicine and Rheumatology, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan.
Mod Rheumatol. 2010 Dec;20(6):632-6. doi: 10.1007/s10165-010-0333-3. Epub 2010 Jul 9.
We present two patients with rheumatoid arthritis (RA) who developed necrotizing crescentic glomerulonephritis (NCGN) during etanercept therapy. Both patients developed proteinuria and hematuria, and one progressed to renal failure. Renal biopsy revealed NCGN. In both patients, nephritis improved following discontinuation of etanercept and administration of prednisolone. Physicians should be aware of etanercept-induced GN in patients with RA on anti-tumor necrosis factor therapy.
我们介绍了 2 例类风湿关节炎（RA）患者，他们在接受依那西普治疗期间发生坏死性新月体肾小球肾炎（NCGN）。这 2 例患者均出现蛋白尿和血尿，其中 1 例进展为肾衰竭。肾活检显示为 NCGN。在这 2 例患者中，停用依那西普并给予泼尼松龙治疗后肾炎均有所改善。对于接受抗肿瘤坏死因子治疗的 RA 患者，医生应注意依那西普引起的 GN。
