Pickworth W B, Bunker E, Welch P, Cone E
National Institute on Drug Abuse, Addiction Research Center, Baltimore, Maryland.
Life Sci. 1991;49(2):129-38. doi: 10.1016/0024-3205(91)90026-8.
The pupillary effects of intravenous buprenorphine were studied in eight nondependent male subjects who reported previous opiate use. Buprenorphine (0.3, 0.6, and 1.2 mg) decreased pupil size, the amplitude of the light reflex, and the velocities of constriction and dilation. Significant pupillary effects occurred within 15 min of the injection and persisted for 24 hr. At 48 hr most measures returned to baseline levels. Generally the magnitude of the effect was not dose related although recovery occurred sooner after the lower dose. The time course of the pupillary effects of buprenorphine exceeds duration of its analgesic and subjective effects. Previous studies have reported that pupillary measures are especially sensitive to the acute effects of full opiate agonists. The results of the present study indicate that buprenorphine, a partial opiate agonist, causes profound and persistent effects on pupillary size and dynamic measures.
在8名有阿片类药物使用史的非成瘾男性受试者中研究了静脉注射丁丙诺啡的瞳孔效应。丁丙诺啡（0.3、0.6和1.2毫克）可使瞳孔大小、光反射幅度以及收缩和扩张速度减小。显著的瞳孔效应在注射后15分钟内出现，并持续24小时。48小时时，大多数指标恢复到基线水平。尽管较低剂量后恢复更快，但一般效应的程度与剂量无关。丁丙诺啡瞳孔效应的时间进程超过其镇痛和主观效应的持续时间。先前的研究报告称，瞳孔测量对完全阿片类激动剂的急性效应特别敏感。本研究结果表明，部分阿片类激动剂丁丙诺啡对瞳孔大小和动态测量有深刻而持久的影响。
