Pickworth W B, Lee H, Fudala P J
National Institute on Drug Abuse, Addiction Research Center, Baltimore, Maryland 21224.
Life Sci. 1990;47(14):1269-77. doi: 10.1016/0024-3205(90)90220-l.
The pupillary effects of the partial opiate agonist buprenorphine were studied in 16 male subjects who were heroin dependent at the time of admission to the study. Sublingual buprenorphine (8 mg) was administered daily for 18 days and continued either daily or on alternate days from study days 19 through 36. On days 37 through 56, all subjects received buprenorphine placebo. Compared to placebo, buprenorphine decreased pupil size and diminished the constriction and dilation velocities of the light reflex. These effects occurred within 5 hours of buprenorphine administration. Following placebo administration during alternate-day dosing of buprenorphine, pupil size increased and constriction and dilation velocities of the light reflex were significantly greater than after buprenorphine administration in the same subjects. This pattern of effects was observed after buprenorphine was discontinued (day 37). The results indicated that buprenorphine has pupillary effects like those of full opiate agonists. The time course of these effects was similar to previously-reported effects of buprenorphine on the electroencephalogram but not to the time course of subjective effects.
在16名入组时对海洛因成瘾的男性受试者中，研究了部分阿片类激动剂丁丙诺啡的瞳孔效应。舌下含服丁丙诺啡（8毫克），每日一次，共18天，从研究第19天至36天，每日或隔日继续给药。在第37天至56天，所有受试者接受丁丙诺啡安慰剂。与安慰剂相比，丁丙诺啡可使瞳孔缩小，并降低光反射的收缩和扩张速度。这些效应在丁丙诺啡给药后5小时内出现。在丁丙诺啡隔日给药期间给予安慰剂后，瞳孔大小增加，且光反射的收缩和扩张速度显著高于同一受试者服用丁丙诺啡后的情况。在丁丙诺啡停药后（第37天）观察到了这种效应模式。结果表明，丁丙诺啡具有与完全阿片类激动剂类似的瞳孔效应。这些效应的时间进程与先前报道的丁丙诺啡对脑电图的效应相似，但与主观效应的时间进程不同。
