Eng J, Ceckler T L, Balaban R S
Laboratory of Cardiac Energetics, National Heart, Lung and Blood Institute, Bethesda, Maryland 20892.
Magn Reson Med. 1991 Feb;17(2):304-14. doi: 10.1002/mrm.1910170203.
A major factor contributing to proton (1H) spin-lattice relaxation in biological tissues is believed to be magnetization transfer between 1H in free bulk water and 1H restricted motion associated with macromolecules. We have shown recently that saturation transfer is an effective approach for studying this magnetization transfer process. Herein the determination of magnetization transfer rates in biological tissues is further analyzed by considering the time and power dependencies of saturation transfer. Following these analyses, quantitative magnetization transfer rate constant image maps were collected from the kidney in vivo. These rate constant images may prove useful in quantitative tissue characterization and in the determination of tissue-specific 1H relaxation mechanisms.
生物组织中质子（1H）自旋晶格弛豫的一个主要因素被认为是自由体水中的1H与与大分子相关的受限运动的1H之间的磁化转移。我们最近表明，饱和转移是研究这种磁化转移过程的有效方法。在此，通过考虑饱和转移的时间和功率依赖性，进一步分析了生物组织中磁化转移率的测定。经过这些分析，在体内从肾脏收集了定量磁化转移率常数图像。这些速率常数图像可能在定量组织表征和组织特异性1H弛豫机制的确定中证明是有用的。
