使用受激回波质子光谱法检测乳酸时存在的一个陷阱。

A pitfall associated with lactate detection using stimulated-echo proton spectroscopy.

作者信息

Sotak C H, Alger J R

机构信息

Department of Biomedical Engineering, Worcester Polytechnic Institute, Massachusetts 01609.

出版信息

Magn Reson Med. 1991 Feb;17(2):533-8. doi: 10.1002/mrm.1910170223.

DOI:10.1002/mrm.1910170223

PMID:2062220

Abstract

At TE values of 136 ms, it has recently been shown that the lactate methyl signal, when obtained with a stimulated-echo (STE) sequence, is modulated at the zero-quantum (ZQ) frequency when TM is varied. Here we describe an additional modulation of the ZQ lactate signal, due to spin-spin coupling, that results in a 10-fold reduction in the lactate signal for TM intervals ranging between 48 and 84 ms (and at multiples of 136 ms thereof). Because of this J-modulation, improper choice of TE and TM intervals may give false negative results for lactate detection by STE spectroscopy.

摘要

在回波时间（TE）为136毫秒时，最近有研究表明，当采用受激回波（STE）序列获取乳酸甲酯信号时，随着横向磁化时间（TM）的变化，零量子（ZQ）频率处的乳酸甲酯信号会受到调制。在此，我们描述了由于自旋 - 自旋耦合导致的ZQ乳酸信号的另一种调制，这种调制使得在TM间隔为48至84毫秒（以及其136毫秒的倍数）时，乳酸信号降低了10倍。由于这种J调制，TE和TM间隔选择不当可能会导致STE光谱法检测乳酸时出现假阴性结果。