Moawad Mahmoud A, Bassil Habib, Elsherif Mona, Ibrahim Abeer, Elnaggar Moustafa, Edathodu Jameela, Alharthi Abdulaziz, Albugami Muneerah, Sabry Ahmed, Shoukri Mohammed, Bakhsh Ibtisam, Laudon Ulrike
Section of Internal Medicine, King Faisal Specialists Hospital and Research Centre, Riyadh, Saudi Arabia.
Ann Saudi Med. 2010 Jul-Aug;30(4):289-94. doi: 10.4103/0256-4947.65259.
Fever of unknown origin (FUO) is mainly secondary to infectious, neoplastic or inflammatory diseases. To increase the body of knowledge on this diagnosis in the region, we collected information on all patients admitted to our institution with FUO in a 13-year period.
We conducted a retrospective chart review of all immunocompetent males and females aged 13 years and older admitted between January 1995 and June 2008 who fulfilled the criteria for FUO. Data collection included demographics, laboratory investigations, imaging studies, procedures and discharge diagnoses. For true FUO, we recorded the duration of follow-up and the outcome.
The 98 patients who met the criteria included 44 males and 54 females with a mean (SD) age of 41.3 (18.5) years and range of 14 to 85 years. The most frequent diagnostic etiology was infectious in 32 (32.7%). Seventeen (17.3%) patients were undiagnosed or had true FUO. Of 9 patients followed up, 8 recovered and 1 expired. The mean duration of follow-up was 20.6 months (range, 0-168 months).
Infectious diseases, especially TB, continue to be the leading etiology of FUO in our area. Our data did not identify any predictor of certain FUO diagnoses except for older age and neoplastic etiology. True FUO patients generally did well. Reporting local experience is important in guiding clinicians about the epidemiologic patterns of FUO in their regions.
不明原因发热（FUO）主要继发于感染性、肿瘤性或炎性疾病。为增加该地区关于此诊断的知识体系，我们收集了13年间在我院收治的所有FUO患者的信息。
我们对1995年1月至2008年6月期间收治的所有符合FUO标准的13岁及以上免疫功能正常的男性和女性患者进行了回顾性病历审查。数据收集包括人口统计学、实验室检查、影像学研究、操作及出院诊断。对于真正的FUO，我们记录了随访时间及结果。
符合标准的98例患者中，男性44例，女性54例，平均（标准差）年龄为41.3（18.5）岁，年龄范围为14至85岁。最常见的诊断病因是感染性疾病，共32例（32.7%）。17例（17.3%）患者未确诊或患有真正的FUO。在接受随访的9例患者中，8例康复，1例死亡。平均随访时间为20.6个月（范围为0至168个月）。
感染性疾病，尤其是结核病，仍然是我们地区FUO的主要病因。除了年龄较大和肿瘤性病因外，我们的数据未发现任何特定FUO诊断的预测因素。真正的FUO患者总体预后良好。报告当地经验对于指导临床医生了解其所在地区FUO的流行病学模式很重要。
