Giełldanowski J, Steuden W
Arch Immunol Ther Exp (Warsz). 1977;25(6):857-62.
The influence of pharmacologic stimulation and blocking of the beta-adrenergic system on appearance of PF and RF cells, and intralymphocytic levels of cAMP were investigated. Stimulation of the beta-adrenergic receptor exerted an immunosuppressive effect, reflected by the numbers of PFC and RFC and raised levels of cAMP. Inhibition of the adrenergic beta-receptor stimulated immunologic responses and lowered levels of cAMP in lymphocytes. Confirmation of a specific adrenergic mechanism was provided by the absence of an effect of stimulation after prior blocking of the receptor. The possibility of a nonspecific membrane effect of beta-adrenergic drugs is discussed.
研究了β-肾上腺素能系统的药理刺激和阻断对PF和RF细胞出现以及淋巴细胞内cAMP水平的影响。β-肾上腺素能受体的刺激产生了免疫抑制作用，这通过PFC和RFC的数量以及cAMP水平的升高得以体现。肾上腺素能β受体的抑制刺激了免疫反应并降低了淋巴细胞内的cAMP水平。在预先阻断受体后刺激无效应，这证实了一种特定的肾上腺素能机制。文中还讨论了β-肾上腺素能药物非特异性膜效应的可能性。
