Tamura H, Aronson B E
Arch Pathol Lab Med. 1978 May;102(5):252-7.
Electron microscopical study of the lung tissue from a 75-year-old man who died of influenza pneumonia (A/Victoria/RI/76) demonstrated fibrillary inclusions in the nuclei of many alveolar lining cells, in bronchial epithelial cells, and also in endothelial cells. These inclusions were morphologically different from those previously reported in experimental animals. In view of previous experimental studies indicating the necessity of nuclear participation in the replication of influenza virus, these inclusions may be virus-induced structures. Also, possibly the presence of these inclusions in the nuclei of many endothelial cells might be indicative of endothelial damage of microvessels and may be a pathogenetically important factor in influenza pneumonia.
对一名死于甲型流感肺炎（A/维多利亚/RI/76）的75岁男性的肺组织进行电子显微镜研究发现，许多肺泡衬里细胞、支气管上皮细胞以及内皮细胞的细胞核内存在纤维状包涵体。这些包涵体在形态上与先前在实验动物中报道的不同。鉴于先前的实验研究表明细胞核参与流感病毒复制的必要性，这些包涵体可能是病毒诱导的结构。此外，许多内皮细胞核中存在这些包涵体可能表明微血管的内皮损伤，并且可能是流感肺炎发病机制中的一个重要因素。
