Department of Neurology, Yonsei University College of Medicine, Seoul, Korea.
Mov Disord. 2010 Sep 15;25(12):1953-9. doi: 10.1002/mds.23185.
A few case-control studies of multiple system atrophy (MSA) have been reported in Western populations. In this study, we included various epidemiological factors to evaluate whether the risk factors for MSA differed in Korean and Western populations. A total of 100 consecutive MSA patients and 104 controls at two referral hospitals participated. Information was obtained through face-to-face interviews using a structured questionnaire: history of living area, occupational history, food habits, alcohol and tobacco consumption, and use of drugs. Odds ratios and 95% confident intervals (OR [95% CI]) were computed using logistic regression. The multivariate logistic regression analysis revealed that use of antihypertensive medication (OR = 0.30 [0.12-0.78]) and vitamins (OR = 0.30 [0.14-0.64]) and consumption of meat and poultry (OR = 0.27 [0.13-0.56]) were associated with decreasing risk for MSA, whereas use of herbal medications (OR = 3.17 [1.28-7.84]) was associated with increasing risk for MSA. In univariate analysis adjusted for age, sex, education level, and recruitment center, use of aspirin (OR = 0.21 [0.07-0.61]) and coffee consumption (OR = 0.44 [0.23-0.84]) were significantly less frequent in MSA patients than in controls, whereas heavy smoking (≥40 pack-years) was significantly more prevalent in MSA patients than in controls (OR = 3.44 [1.05-11.23]). There was no difference in living area, participation in farming, or exposure to agrichemicals and solvents between groups. This study showed that MSA in Korea is characterized by risk factors that are both similar to and different from those affecting Western populations and that herbal medicines constitute a new MSA risk factor for the Korean population.
一些关于多系统萎缩症（MSA）的病例对照研究已经在西方人群中报道过。在这项研究中，我们纳入了各种流行病学因素，以评估 MSA 的危险因素在韩国和西方人群中是否存在差异。我们共纳入了两家转诊医院的 100 例连续 MSA 患者和 104 例对照者。通过使用结构化问卷进行面对面访谈获取信息：居住地区史、职业史、饮食习惯、烟酒使用情况和药物使用情况。使用逻辑回归计算比值比和 95%置信区间（OR [95%CI]）。多变量逻辑回归分析显示，使用抗高血压药物（OR=0.30 [0.12-0.78]）和维生素（OR=0.30 [0.14-0.64]）以及食用肉类和家禽（OR=0.27 [0.13-0.56]）与 MSA 风险降低相关，而使用草药药物（OR=3.17 [1.28-7.84]）与 MSA 风险增加相关。在调整年龄、性别、教育程度和招募中心后进行的单变量分析中，与对照组相比，MSA 患者使用阿司匹林（OR=0.21 [0.07-0.61]）和咖啡（OR=0.44 [0.23-0.84]）的频率显著降低，而重度吸烟（≥40 包年）在 MSA 患者中更为常见（OR=3.44 [1.05-11.23]）。两组在居住地区、务农参与情况或暴露于农用化学品和溶剂方面没有差异。本研究表明，韩国的 MSA 具有与影响西方人群的危险因素相似和不同的危险因素，草药药物构成了韩国人群的新 MSA 危险因素。
