Department of Neurology, Mayo Clinic, Rochester, MN, USA.
Department of Neurology, Mayo Clinic, Rochester, MN, USA.
Parkinsonism Relat Disord. 2019 Sep;66:212-215. doi: 10.1016/j.parkreldis.2019.07.015. Epub 2019 Jul 17.
To determine whether smoking or alcohol use impacts the age of onset and disease duration in multiple system atrophy (MSA).
All patients diagnosed with MSA at Mayo Clinic, Rochester between 1998 and 2012 completed standardized questionnaires surveying smoking and alcohol use at the time of presentation.
Of 551 patients with smoking and alcohol use data, 281 were past or present smokers with age of onset of 60.76 years compared to 62.97 years in controls (p = 0.0144). Age of onset in the 87 heavy alcohol users was 56.87 years compared to 62.97 years in controls (p = 0.0133). There was no difference in disease duration for smokers (p = 0.2758) or heavy alcohol users (p = 0.4820) compared to controls.
Our findings show that smoking history and/or heavy alcohol use is associated with younger age of onset in MSA but do not influence survival.
确定吸烟或饮酒是否会影响多系统萎缩（MSA）的发病年龄和病程。
1998 年至 2012 年期间，在梅奥诊所罗切斯特分校被诊断为 MSA 的所有患者均完成了标准化问卷，以调查其就诊时的吸烟和饮酒情况。
在 551 名有吸烟和饮酒数据的患者中，281 名患者为过去或现在的吸烟者，发病年龄为 60.76 岁，而对照组为 62.97 岁（p=0.0144）。87 名重度饮酒者的发病年龄为 56.87 岁，而对照组为 62.97 岁（p=0.0133）。与对照组相比，吸烟者（p=0.2758）或重度饮酒者（p=0.4820）的病程无差异。
我们的研究结果表明，吸烟史和/或大量饮酒与 MSA 的发病年龄较小有关，但不影响生存。
