Tbx3：多能干细胞谜题中又一个重要的部分。
Tbx3: another important piece fitted into the pluripotent stem cell puzzle.
出版信息
Stem Cell Res Ther. 2010 May 20;1(2):12. doi: 10.1186/scrt12.
Abstract
Induced pluripotent stem cells (iPSCs) are novel tools for biomedical research, with a promise for future regenerative medicine applications. Recently, Han and colleagues reported in Nature that T box gene 3 (Tbx3) can improve the quality of mouse iPSCs and increase their germline transmission efficacy. This observation contributes greatly to the improvement of iPSC technology and might be a step towards 'designer' reprogramming strategies by generating high quality iPSCs. Further studies comparing pluripotency regulation in different species, including that in human, will be necessary to verify the universal role of Tbx3 and the medical relevance of the observation.
摘要
诱导多能干细胞（iPSCs）是生物医学研究的新型工具，有望在未来的再生医学应用中得到应用。最近，Han 及其同事在《自然》杂志上报道称，T 框基因 3（Tbx3）可以提高小鼠 iPSCs 的质量，并提高其种系传递效率。这一观察结果极大地促进了 iPSC 技术的改进，可能是通过生成高质量的 iPSCs 朝着“设计”重编程策略迈出的一步。进一步比较不同物种（包括人类）中的多能性调控的研究，将是验证 Tbx3 的普遍作用和观察结果的医学相关性所必需的。
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