Psychol Med. 2011 Jan;41(1):7-13. doi: 10.1017/S0033291710000413. Epub 2010 Mar 29.
This article examines a model of how delusions may arise, not just in schizophrenia but also in a number of neurological and psychiatric conditions, through a combination of dysregulated dopamine release from ascending midbrain pathways and reasoning bias. Negative symptoms may also be related to dopamine dysregulation, with the precise mixture of positive and negative symptoms depending on the relative degree of dopamine dysregulation in particular mesocorticolimbic circuits. Evidence for this model is examined, and predictions arising from this model are described.
本文探讨了一种妄想如何产生的模型，不仅在精神分裂症中如此，在许多神经和精神疾病中也是如此，这是通过中脑上行途径多巴胺释放失调和推理偏差的结合而产生的。阴性症状也可能与多巴胺失调有关，具体的阳性和阴性症状的混合取决于特定的中边缘皮质回路中多巴胺失调的相对程度。本文检验了该模型的证据，并描述了该模型产生的预测。
