自闭症谱系中的基因组变异和复杂性。
Genome variation and complexity in the autism spectrum.
机构信息
Genes to Cognition Programme, Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire, UK.
出版信息
Neuron. 2010 Jul 15;67(1):8-10. doi: 10.1016/j.neuron.2010.06.026.
PMID:20624587
Abstract
A large international consortium reports in Nature on the diversity of genomic changes in families with autism spectrum disorders. Inherited and de novo mutations affecting many genes were discovered implicating disruption to postsynaptic and cellular signaling processes.
摘要
一个大型国际研究团队在《自然》杂志上报告了自闭症谱系障碍患者家庭中基因组变化的多样性。研究发现了影响许多基因的遗传和新生突变，这些突变涉及到突触后和细胞信号转导过程的破坏。
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