Serologic and pathogenicity studies of avian adenovirus isolated from chickens with inclusion body hepatitis.

A virus initially thought to be inclusion body hepatitis virus (IBHV), Tipton strain, was classified as an avian adenovirus (AAV) and shown to be antigenically related to 2 serotypes of AAV, 764 and YR36. The virus was antigenically unrelated to AAV serotype TR-22, which included IBHV, Tipton strain. Inoculating specific-pathogen-free chickens with the virus produced hepatitis with basophilic and eosinophilic staining intranuclear inclusion bodies.