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摄入过多过少都会导致问题：木糖醇，一种引发慢性代谢性高氯性酸中毒的不寻常物质。

Too much of too little: xylitol, an unusual trigger of a chronic metabolic hyperchloremic acidosis.

机构信息

Department of Intensive Care and Neonatology, University Children's Hospital, Steinwiesstr. 75, CH-8032 Zurich, Switzerland.

出版信息

Eur J Pediatr. 2010 Dec;169(12):1549-51. doi: 10.1007/s00431-010-1249-9. Epub 2010 Jul 13.

DOI:10.1007/s00431-010-1249-9
PMID:20625910
Abstract

Homeopathic globules are frequently used in children as a first-line treatment. Most of these globules are coated with sugar substitutes like xylitol; these substitutes are known for their laxative effect. Our patient shows that consumption of globules coated with xylitol does not have only laxative effects. It may cause indeed considerable weight loss and life-threatening enteral bicarbonate loss by diarrhea when overdosed in an infant.

摘要

顺势疗法球经常被用于儿童作为一线治疗。这些球中的大多数都涂有木糖醇等糖替代品；这些替代品以其通便作用而闻名。我们的患者表明，涂有木糖醇的球的消耗不仅具有通便作用。当婴儿过量服用时，它确实可能通过腹泻导致相当大的体重减轻和危及生命的碳酸氢盐损失。

相似文献

1
Too much of too little: xylitol, an unusual trigger of a chronic metabolic hyperchloremic acidosis.摄入过多过少都会导致问题：木糖醇，一种引发慢性代谢性高氯性酸中毒的不寻常物质。
Eur J Pediatr. 2010 Dec;169(12):1549-51. doi: 10.1007/s00431-010-1249-9. Epub 2010 Jul 13.
2
Threshold for transitory diarrhea induced by ingestion of xylitol and lactitol in young male and female adults.年轻成年男性和女性摄入木糖醇和乳糖醇引起短暂性腹泻的阈值。
J Nutr Sci Vitaminol (Tokyo). 2007 Feb;53(1):13-20. doi: 10.3177/jnsv.53.13.
3
Tolerability of oral xylitol solution in young children: implications for otitis media prophylaxis.幼儿口服木糖醇溶液的耐受性：对中耳炎预防的意义
Int J Pediatr Otorhinolaryngol. 2007 Jan;71(1):89-94. doi: 10.1016/j.ijporl.2006.09.008. Epub 2006 Nov 9.
4
Chronic diarrhea with hyperchloremic acidosis and hypokalemia.伴有高氯性酸中毒和低钾血症的慢性腹泻
Gastroenterology. 2012 Jan;142(1):e22-3. doi: 10.1053/j.gastro.2011.01.065. Epub 2011 Nov 19.
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Xylitol toxicity in dogs.犬木糖醇中毒
Vet Rec. 2008 Feb 23;162(8):254. doi: 10.1136/vr.162.8.254-c.
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Hyperchloremic normal gap metabolic acidosis.高氯性正常阴离子间隙代谢性酸中毒
Minerva Endocrinol. 2019 Dec;44(4):363-377. doi: 10.23736/S0391-1977.19.03059-1. Epub 2019 Jul 24.
7
[Side effects of sugar substitutes].[代糖的副作用]
Dtsch Zahnarztl Z. 1977;32(5 Suppl 1):S43-53.
8
Xylitol and dental disease.木糖醇与牙齿疾病。
N Z Dent J. 1977 Jul;73(333):159-61.
9
Urinary net charge in hyperchloremic metabolic acidosis.高氯性代谢性酸中毒时的尿净电荷
Indian Pediatr. 1998 Jan;35(1):13-8.
10
What is your diagnosis? Hypoglycaemia.你的诊断是什么？低血糖症。
J Small Anim Pract. 2008 Jan;49(1):47-9. doi: 10.1111/j.1748-5827.2007.00518.x.

引用本文的文献

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Recent advances in understanding and managing infantile colic.婴幼儿腹绞痛理解与管理的最新进展
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本文引用的文献

1
Accidental intakes of remedies from complementary and alternative medicine in children--analysis of data from the Swiss Toxicological Information Centre.儿童意外摄入补充和替代医学药物——瑞士毒物信息中心数据分析。
Eur J Pediatr. 2010 Jun;169(6):681-8. doi: 10.1007/s00431-009-1087-9. Epub 2009 Oct 13.
2
The potential of dental-protective chewing gum in oral health interventions.牙齿保护口香糖在口腔健康干预中的潜力。
J Am Dent Assoc. 2008 May;139(5):553-63. doi: 10.14219/jada.archive.2008.0215.
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Surveillance of suspected adverse reactions to natural health products in Italy.
意大利对天然健康产品疑似不良反应的监测。
Pharmacoepidemiol Drug Saf. 2008 Jun;17(6):626-35. doi: 10.1002/pds.1566.
4
Threshold for transitory diarrhea induced by ingestion of xylitol and lactitol in young male and female adults.年轻成年男性和女性摄入木糖醇和乳糖醇引起短暂性腹泻的阈值。
J Nutr Sci Vitaminol (Tokyo). 2007 Feb;53(1):13-20. doi: 10.3177/jnsv.53.13.
5
Tolerability of oral xylitol solution in young children: implications for otitis media prophylaxis.幼儿口服木糖醇溶液的耐受性：对中耳炎预防的意义
Int J Pediatr Otorhinolaryngol. 2007 Jan;71(1):89-94. doi: 10.1016/j.ijporl.2006.09.008. Epub 2006 Nov 9.
6
Nutritional significance of fructose and sugar alcohols.果糖和糖醇的营养意义。
Annu Rev Nutr. 1981;1:437-75. doi: 10.1146/annurev.nu.01.070181.002253.
7
Xylitol vs glucose: effect on the rate of gastric emptying and motilin, insulin, and gastric inhibitory polypeptide release.木糖醇与葡萄糖：对胃排空速率以及胃动素、胰岛素和胃抑制性多肽释放的影响。
Am J Clin Nutr. 1989 Jun;49(6):1228-32. doi: 10.1093/ajcn/49.6.1228.