Patel S, Tariot P N
University of Rochester School of Medicine, New York.
Psychiatr Clin North Am. 1991 Jun;14(2):287-308.
The disruption of multiple neurotransmitter systems in Alzheimer's disease plays an important role in the pathophysiology of cognitive and behavioral disturbances associated with the illness. The central cholinergic system is significantly disrupted in a fashion that correlates with cognitive impairment. This article describes drugs, such as scopolamine, that selectively affect the cholinergic system and model aspects of Alzheimer's disease phenomenology in both animals and humans. Drugs that induce cognitive changes but whose chemical mechanisms are not well understood are presented as alternative pharmacologic models of Alzheimer's disease.
阿尔茨海默病中多种神经递质系统的紊乱在与该疾病相关的认知和行为障碍的病理生理学中起着重要作用。中枢胆碱能系统以与认知障碍相关的方式受到显著破坏。本文介绍了东莨菪碱等药物，这些药物选择性地影响胆碱能系统，并在动物和人类中模拟阿尔茨海默病现象学的各个方面。还介绍了能引起认知变化但其化学机制尚不清楚的药物，作为阿尔茨海默病的替代药理学模型。
