Tariot P N, Patel S V, Cox C, Henderson R E
Department of Psychiatry, University of Rochester School of Medicine and Dentistry, New York, USA.
Psychopharmacology (Berl). 1996 May;125(1):50-6. doi: 10.1007/BF02247392.
Scopolamine hydrobromide was administered intravenously to 23 normal subjects (40-89 years) in doses of 0.1 mg, 0.25 mg, and 0.5 mg, in a double-blind. Placebo-controlled, random-order fashion. The effects of scopolamine, as compared to placebo, were assessed using a comprehensive cognitive test battery, as well as behavioral and physiological measures. Scopolamine produced the expected dose-dependent impairments in most of the cognitive functions assessed. Behavioral and physiological measures were also affected, but only minimally. More importantly, there was a significant overall correlation between age and scopolamine-impaired performances on psychomotor speed, short-term recall, visual tracking speed, visuo-motor coordination, and sequencing ability. There was, however, some inter-individual variability in this phenomenon. The results provide further evidence that cholinergically mediated cognitive functions show an increased sensitivity to scopolamine with age, albeit with heterogeneity that bears further investigation.
对23名年龄在40至89岁的正常受试者进行了双盲、安慰剂对照、随机顺序的静脉注射氢溴酸东莨菪碱试验，剂量分别为0.1毫克、0.25毫克和0.5毫克。与安慰剂相比，使用一套全面的认知测试以及行为和生理测量方法评估了东莨菪碱的效果。在评估的大多数认知功能中，东莨菪碱产生了预期的剂量依赖性损害。行为和生理测量也受到影响，但程度很小。更重要的是，年龄与东莨菪碱导致的心理运动速度、短期记忆、视觉跟踪速度、视觉运动协调和序列能力受损表现之间存在显著的总体相关性。然而，这种现象存在一些个体间差异。结果进一步证明，胆碱能介导的认知功能随着年龄增长对东莨菪碱的敏感性增加，尽管存在异质性，仍需进一步研究。
