急性脑出血患者脑微出血与低血清胆固醇之间无关联。
Lack of association between cerebral microbleeds and low serum cholesterol in patients with acute intracerebral hemorrhage.
作者信息
Orken Dilek Necioglu, Kenangil Gulay, Uysal Ender, Gundogdu Lale, Erginoz Ethem, Forta Hulki
机构信息
Sisli Etfal Education and Research Hospital, Department of Neurology, Istanbul, Turkey.
出版信息
Clin Neurol Neurosurg. 2010 Oct;112(8):668-71. doi: 10.1016/j.clineuro.2010.05.004. Epub 2010 Jun 2.
BACKGROUND
The association of cerebral microbleeds (CMBs) with intracerebral hemorrhage (ICH) is well known and its relationship with low serum cholesterol in ICH patients might be of interest.
METHODS
A total of 105 patients with ICH were evaluated. In all subjects cholesterol levels were measured after 12h of fasting and gradient-echo magnetic resonance imaging (GE-MRI) was performed for detecting CMBs.
RESULTS
CMBs were more common among patients with hypertension and leukoaraiosis (p=0.008 and p=0.001). Patients with and without CMBs did not differ according to total cholesterol, LDL cholesterol, triglycerides and HDL cholesterol levels.
CONCLUSION
In this study, 61% of Turkish ICH patients had CMBs, which was not associated with lipid profiles. Leukoaraiosis was independently associated with CMBs.
背景
脑微出血（CMB）与脑出血（ICH）的关联已为人熟知，其与ICH患者低血清胆固醇之间的关系可能值得关注。
方法
共评估了105例ICH患者。所有受试者在禁食12小时后测量胆固醇水平，并进行梯度回波磁共振成像（GE-MRI）以检测CMB。
结果
CMB在高血压和脑白质疏松患者中更为常见（p = 0.008和p = 0.001）。有和没有CMB的患者在总胆固醇、低密度脂蛋白胆固醇、甘油三酯和高密度脂蛋白胆固醇水平方面没有差异。
结论
在本研究中，61%的土耳其ICH患者有CMB，这与血脂谱无关。脑白质疏松与CMB独立相关。
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