组胺对人胎盘绒毛膜静脉的影响：与血清素的相互作用。

Effect of histamine on human placental chorionic veins: interaction with serotonin.

作者信息

Cruz M A, González C, Sepúlveda W H, Rudolph M I

机构信息

Departamentos de Ciencias Fisiológicas y de Histología y Embriología, Facultad de Ciencias Biológicas y de Recursos Naturales, Universidad de Concepción, Chile.

出版信息

Pharmacology. 1991;42(2):86-90. doi: 10.1159/000138777.

DOI:10.1159/000138777

PMID:2062875

Abstract

The vasomotor effects of histamine and its interaction with serotonin were studied in isolated human placental chorionic veins. Histamine induced concentration-dependent contractions with an EC50 of 8.7 +/- 1.2 x 10(-6) mol/l. The H1 antagonist, pyrilamine (10(-9) to 10(-7) mol/l), inhibited histamine-induced contractions, with a pA2 of 8.33 +/- 0.32 at a slope of 0.635. Cimetidine (H2 antagonist) had no effect on histamine-induced contractions. Serotonin (10(-9) to 10(-8) mol/l) significantly potentiated the contractile effect of histamine. The possible implications of the interaction between both amines in the regulation of placental blood flow is discussed.

摘要

在离体人胎盘绒毛膜静脉中研究了组胺的血管舒缩效应及其与5-羟色胺的相互作用。组胺引起浓度依赖性收缩，半数有效浓度（EC50）为8.7±1.2×10⁻⁶mol/L。H1拮抗剂吡苄明（10⁻⁹至10⁻⁷mol/L）抑制组胺引起的收缩，在斜率为0.635时，其拮抗常数（pA2）为8.33±0.32。西咪替丁（H2拮抗剂）对组胺引起的收缩无影响。5-羟色胺（10⁻⁹至10⁻⁸mol/L）显著增强组胺的收缩作用。文中讨论了两种胺类之间相互作用在胎盘血流调节中的可能意义。